Gao SS, Zhang ZK, Wang XB, Ma Y, Yin GQ, Guo XB. Role of transcribed ultraconserved regions in gastric cancer and therapeutic perspectives. World J Gastroenterol 2022; 28(25): 2900-2909 [PMID: 35978878 DOI: 10.3748/wjg.v28.i25.2900]
Corresponding Author of This Article
Xiao-Bo Guo, PhD, Doctor, Department of Gastrointestinal Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, No. 324 Jingwu Road, Huaiyin District, Jinan 250021, Shandong Province, China. guo992352@hotmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Shen-Shuo Gao, Zhi-Kai Zhang, Yan Ma, Xiao-Bo Guo, Department of Gastrointestinal Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250021, Shandong Province, China
Xu-Bin Wang, Yan Ma, Xiao-Bo Guo, Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong Province, China
Guo-Qing Yin, Department of Anus and Intestine Surgery, Qingzhou Hospital Affiliated to Shandong First Medical University, Qingzhou 262500, Shandong Province, China
Author contributions: Guo XB and Gao SS conceived of the presented idea and researched the background of the study; Zhang ZZ and Wang XB prepared the figures and tables; Ma Y and Yin GQ wrote the manuscript; all the authors read and approved the final manuscript.
Supported byNational Natural Science Foundation of China, No. 81672379 and No. 81101858; and Natural Science Foundation of Shandong Province, China, No. ZR2016HM16.
Conflict-of-interest statement: There is no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Bo Guo, PhD, Doctor, Department of Gastrointestinal Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, No. 324 Jingwu Road, Huaiyin District, Jinan 250021, Shandong Province, China. guo992352@hotmail.com
Received: February 21, 2022 Peer-review started: February 21, 2022 First decision: April 5, 2022 Revised: April 8, 2022 Accepted: May 28, 2022 Article in press: May 28, 2022 Published online: July 7, 2022
Abstract
Gastric cancer (GC) is the fourth leading cause of cancer-related death. The occurrence and development of GC is a complex process involving multiple biological mechanisms. Although traditional regulation modulates molecular functions related to the occurrence and development of GC, the comprehensive mechanisms remain unclear. Ultraconserved region (UCR) refers to a genome sequence that is completely conserved in the homologous regions of the human, rat and mouse genomes, with 100% identity, without any insertions or deletions, and often located in fragile sites and tumour-related genes. The transcribed UCR (T-UCR) is transcribed from the UCR and is a new type of long noncoding RNA. Recent studies have found that the expression level of T-UCRs changes during the occurrence and development of GC, revealing a new mechanism underlying GC. Therefore, this article aims to review the relevant research on T-UCRs in GC, as well as the function of T-UCRs and their regulatory role in the occurrence and development of GC, to provide new strategies for GC diagnosis and treatment.
Core Tip: Transcribed ultraconserved region (T-UCR) is abnormally expressed in gastric cancer (GC) cells and tumors. It has been found that a variety of T-UCR affects downstream genes and related pathways, and plays a regulatory role in the proliferation, migration and invasion of GC. However, there are few relevant reviews, and this paper aims to review the related studies of T-UCR in GC. And the function of T-UCR and its regulatory role in the occurrence and development of GC, thus providing a new strategy for the diagnosis and treatment of GC.
