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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 28, 2022; 28(16): 1656-1670
Published online Apr 28, 2022. doi: 10.3748/wjg.v28.i16.1656
Published online Apr 28, 2022. doi: 10.3748/wjg.v28.i16.1656
LncRNA cancer susceptibility 20 regulates the metastasis of human gastric cancer cells via the miR-143-5p/MEMO1 molecular axis
Ke-Shu Shan, Shuai Kong, Li-Pan Peng, Hong-Qing Zhuo, Shu-Bo Tian, Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong Province, China
Ke-Shu Shan, Shuai Kong, Li-Pan Peng, Hong-Qing Zhuo, Shu-Bo Tian, Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong Province, China
Wei-Wei Li, Department of Critical Care Medicine, The 960th Hospital of the People's Liberation Army Joint Logistics Support Force, Jinan 250031, Shandong Province, China
Wang Ren, Department of General Surgery, People's Hospital of Sishui County, Jining 273200, Shandong Province, China
Author contributions: Shan KS and Li WW contributed equally to this work; Tian SB and Shan KS designed the study; Shan KS, Li WW and Ren W performed all experiments; Kong S and Peng LP collected tissue samples and the clinical data; Shan KS and Li WW analyzed and interpreted the data; Tian SB and Zhuo HQ drafted the manuscript; all authors read and approved the final manuscript.
Supported by Shandong Province Medicine and Health Science and Technology Development Plan Project , No. 2019WS477 .
Institutional review board statement: The study was reviewed and approved by the Shandong Provincial Hospital Institutional Review Board, No. SZRJJ: NO. 2020.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shu-Bo Tian, PhD, Chief Doctor, Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong Province, China. ttkl_bo@126.com
Received: October 19, 2021
Peer-review started: October 19, 2021
First decision: December 12, 2021
Revised: December 26, 2021
Accepted: March 25, 2022
Article in press: March 25, 2022
Published online: April 28, 2022
Processing time: 186 Days and 15.9 Hours
Peer-review started: October 19, 2021
First decision: December 12, 2021
Revised: December 26, 2021
Accepted: March 25, 2022
Article in press: March 25, 2022
Published online: April 28, 2022
Processing time: 186 Days and 15.9 Hours
Core Tip
Core Tip: LncRNA cancer susceptibility 20 (CASC20) is upregulated in gastric cancer (GC) and associated with a higher risk of lymphatic metastasis and poor prognosis of patients. CASC20 can promote the proliferation, invasion and metastasis of GC cells by absorbing miR-143-5p to upregulate MEMO1, thereby induced epithelial-mesenchymal transition in vitro.