Review
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World J Gastroenterol. Mar 28, 2022; 28(12): 1204-1219
Published online Mar 28, 2022. doi: 10.3748/wjg.v28.i12.1204
Antibiotics, gut microbiota, and irritable bowel syndrome: What are the relations?
Zarina Mamieva, Elena Poluektova, Valery Svistushkin, Vasily Sobolev, Oleg Shifrin, Francisco Guarner, Vladimir Ivashkin
Zarina Mamieva, Elena Poluektova, Oleg Shifrin, Vladimir Ivashkin, Department of Internal Disease Propaedeutics, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119991, Russia
Valery Svistushkin, Vasily Sobolev, Department of Ear, Throat and Nose Diseases, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119991, Russia
Francisco Guarner, Digestive System Research Unit, Vall d’Hebron Research Institute, Barcelona 08035, Spain
Author contributions: Mamieva Z and Poluektova E took the lead in writing the manuscript; Svistushkin V and Sobolev V contributed to interpreting the relevant literature, provided critical feedback, and helped shape the manuscript; Shifrin O, Guarner F, and Ivashkin V substantially contributed to the conception and design of the article and revised the paper; all authors read and approved the final manuscript.
Conflict-of-interest statement: The authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zarina Mamieva, MD, Research Assistant, Department of Internal Disease Propaedeutics, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), No. 8 bld. 2 Trubetskaya st., Moscow 119991, Russia. mamievazarina@mail.ru
Received: August 24, 2021
Peer-review started: August 24, 2021
First decision: November 7, 2021
Revised: December 1, 2021
Accepted: February 22, 2022
Article in press: February 22, 2022
Published online: March 28, 2022
Core Tip

Core Tip: Irritable bowel syndrome (IBS) is among the most common gastrointestinal disorders; however, its etiology and underlying pathophysiology have yet to be fully elucidated. The present review focuses on the existing evidence on the pathogenic role of the gut microbiota in the development of IBS. Moreover, it provides a comprehensive review on the magnitude of changes in the gut microbiota in response to antibiotics. The paper contributes to a deeper understanding of the link between antibiotic use and the development of IBS.