Randomized Controlled Trial
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 14, 2016; 22(46): 10242-10248
Published online Dec 14, 2016. doi: 10.3748/wjg.v22.i46.10242
Randomized controlled study of the safety and efficacy of nitrous oxide-sedated endoscopic ultrasound-guided fine needle aspiration for digestive tract diseases
Cai-Xia Wang, Jian Wang, Yuan-Yuan Chen, Jia-Ni Wang, Xin Yu, Feng Yang, Si-Yu Sun
Cai-Xia Wang, Yuan-Yuan Chen, Jia-Ni Wang, Xin Yu, Feng Yang, Si-Yu Sun, Endoscopy Center, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Jian Wang, Endoscopic Center, Liao Dongwan Branch Courts, Shengjing Hospital of China Medical University, Dawa county town, Panjin 124200, Liaoning Province, China
Author contributions: Wang CX, Wang J and Chen YY performed the majority of experiments; Wang CX and Wang JN provided vital reagents and analytical tools and were also involved in writing and revising the manuscript; Yu X and Yang F provided the collection of all the human material; and Sun SY designed the study and wrote the manuscript.
Institutional review board statement: This study was approved by the Institutional Review Board and Ethics Committee of China Medical University (clinical trial registration number: ChiCTR-OCC-15005853).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Si-Yu Sun, MD, PhD, Professor, Endoscopy Center, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Shenyang 110004, Liaoning Province, China. sun-siyu@163.com
Telephone: +86-24-86176688
Received: October 18, 2016
Peer-review started: October 19, 2016
First decision: November 14, 2016
Revised: November 21, 2016
Accepted: December 2, 2016
Article in press: December 2, 2016
Published online: December 14, 2016
Processing time: 55 Days and 4.3 Hours
Core Tip

Core tip: Endoscopic ultrasonography (EUS) has been widely used in the diagnosis and treatment of gastrointestinal tract and pancreaticobiliary diseases. However, EUS-guided fine needle aspiration (EUS-FNA) is a time-consuming procedure associated with pain and discomfort. Nitrous oxide, also known as laughing gas, is a colorless, short-acting inhaled agent that can produce anesthetic, analgesic, and anxiolytic effects. Safety and efficacy of nitrous oxide-sedated EUS-FNA. However, inhaled nitrous oxide has no effect on heart or lung function and patients remain awake, and this thus represents a feasible mode of sedation for EUS. The current study aimed to establish the safe.