Wang CX, Wang J, Chen YY, Wang JN, Yu X, Yang F, Sun SY. Randomized controlled study of the safety and efficacy of nitrous oxide-sedated endoscopic ultrasound-guided fine needle aspiration for digestive tract diseases. World J Gastroenterol 2016; 22(46): 10242-10248 [PMID: 28028373 DOI: 10.3748/wjg.v22.i46.10242]
Corresponding Author of This Article
Si-Yu Sun, MD, PhD, Professor, Endoscopy Center, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Shenyang 110004, Liaoning Province, China. sun-siyu@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Randomized Controlled Trial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Dec 14, 2016; 22(46): 10242-10248 Published online Dec 14, 2016. doi: 10.3748/wjg.v22.i46.10242
Randomized controlled study of the safety and efficacy of nitrous oxide-sedated endoscopic ultrasound-guided fine needle aspiration for digestive tract diseases
Cai-Xia Wang, Yuan-Yuan Chen, Jia-Ni Wang, Xin Yu, Feng Yang, Si-Yu Sun, Endoscopy Center, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Jian Wang, Endoscopic Center, Liao Dongwan Branch Courts, Shengjing Hospital of China Medical University, Dawa county town, Panjin 124200, Liaoning Province, China
Author contributions: Wang CX, Wang J and Chen YY performed the majority of experiments; Wang CX and Wang JN provided vital reagents and analytical tools and were also involved in writing and revising the manuscript; Yu X and Yang F provided the collection of all the human material; and Sun SY designed the study and wrote the manuscript.
Institutional review board statement: This study was approved by the Institutional Review Board and Ethics Committee of China Medical University (clinical trial registration number: ChiCTR-OCC-15005853).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Si-Yu Sun, MD, PhD, Professor, Endoscopy Center, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Shenyang 110004, Liaoning Province, China. sun-siyu@163.com
Telephone: +86-24-86176688
Received: October 18, 2016 Peer-review started: October 19, 2016 First decision: November 14, 2016 Revised: November 21, 2016 Accepted: December 2, 2016 Article in press: December 2, 2016 Published online: December 14, 2016 Processing time: 55 Days and 4.3 Hours
Abstract
AIM
To evaluate the efficacy and safety of nitrous oxide-sedated endoscopic ultrasound-guided fine needle aspiration.
METHODS
Enrolled patients were divided randomly into an experimental group (inhalation of nitrous oxide) and a control group (inhalation of pure oxygen) and heart rate, blood oxygen saturation, blood pressure, electrocardiogram (ECG) changes, and the occurrence of complications were monitored and recorded. All patients and physicians completed satisfaction questionnaires about the examination and scored the process using a visual analog scale.
RESULTS
There was no significant difference in heart rate, blood oxygen saturation, blood pressure, ECG changes, or complication rate between the two groups of patients (P > 0.05). However, patient and physician satisfaction were both significantly higher in the nitrous oxide compared with the control group (P < 0.05).
CONCLUSION
Nitrous oxide-sedation is a safe and effective option for patients undergoing endoscopic ultrasound-guided fine needle aspiration.
Core tip: Endoscopic ultrasonography (EUS) has been widely used in the diagnosis and treatment of gastrointestinal tract and pancreaticobiliary diseases. However, EUS-guided fine needle aspiration (EUS-FNA) is a time-consuming procedure associated with pain and discomfort. Nitrous oxide, also known as laughing gas, is a colorless, short-acting inhaled agent that can produce anesthetic, analgesic, and anxiolytic effects. Safety and efficacy of nitrous oxide-sedated EUS-FNA. However, inhaled nitrous oxide has no effect on heart or lung function and patients remain awake, and this thus represents a feasible mode of sedation for EUS. The current study aimed to establish the safe.