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World J Gastroenterol. May 21, 2015; 21(19): 5823-5830
Published online May 21, 2015. doi: 10.3748/wjg.v21.i19.5823
Contribution of the IL-17/IL-23 axis to the pathogenesis of inflammatory bowel disease
Cristina-Sorina Cătană, Ioana Berindan-Neagoe, Vasile Cozma, Cristian Magdaş, Flaviu Tăbăran, Dan Lucian Dumitraşcu
Cristina-Sorina Cătană, Department of Medical Biochemistry, “Iuliu Haţieganu” University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania
Ioana Berindan-Neagoe, Department of Immunology, “Iuliu Haţieganu” University of Medicine and Pharmacy, 400174 Cluj-Napoca, Romania
Vasile Cozma, Cristian Magdaş, Department of Parasitology and Parasitic Diseases, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania
Flaviu Tăbăran, Department of Morphopathology, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania
Dan Lucian Dumitraşcu, 2nd Medical Department, “Iuliu Haţieganu” University of Medicine and Pharmacy, 400003 Cluj-Napoca, Romania
Author contributions: Cătană CS initiated this review, searched the literature and contributed largely to the writing of the manuscript; Cozma V, Berindan-Neagoe I and Dumitraşcu DL contributed with their own opinions to this review, surveyed and adviced the literature search, offered suggestions on the structure of this paper, contributed to the writing, reviewed all the versions of the manuscript and gave the final approval of the version to be published; Magdaş C and Tăbăran F drafted the article and revised it critically for important intellectual content.
Supported by grants from “Iuliu Haţieganu” University, No. 1495/9/28.01.2014 (to Cristina-Sorina Cătană); and POSDRU project, No. 159/1.5/S/136893, published under the frame of European Social Fund, Human Resources Development Operational Programme 2007-2013 to (Cristian Magdaş).
Conflict-of-interest: None of the authors have conflict of interest in respect to this paper.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Cristian Magdaş, DVM, PhD, Lecturer, Department of Parasitology and Parasitic Diseases, University of Agricultural Sciences and Veterinary Medicine, Calea Mănăştur 3-5, 400372 Cluj-Napoca, Romania. cmagdas@usamvcluj.ro
Telephone: +40-264-596384 Fax: +40-264-593792
Received: October 12, 2014
Peer-review started: October 13, 2014
First decision: November 14, 2014
Revised: December 4, 2014
Accepted: January 21, 2015
Article in press: January 21, 2015
Published online: May 21, 2015
Processing time: 219 Days and 21.2 Hours
Core Tip

Core tip: The pathogenesis of inflammatory bowel diseases (Crohn’s disease and ulcerative colitis) is multifactorial and still not completely understood. There is a need to identify new diagnostic biomarkers as well as an efficient therapy for these diseases. A better understanding of the immunological mechanisms that control gut inflammation, is of high clinical importance because it offers the possibility to develop new drugs, which attack the key pro-inflammatory pathways in chronic intestinal inflammation.