Cătană CS, Berindan-Neagoe I, Cozma V, Magdaş C, Tăbăran F, Dumitraşcu DL. Contribution of the IL-17/IL-23 axis to the pathogenesis of inflammatory bowel disease. World J Gastroenterol 2015; 21(19): 5823-5830 [PMID: 26019446 DOI: 10.3748/wjg.v21.i19.5823]
Corresponding Author of This Article
Cristian Magdaş, DVM, PhD, Lecturer, Department of Parasitology and Parasitic Diseases, University of Agricultural Sciences and Veterinary Medicine, Calea Mănăştur 3-5, 400372 Cluj-Napoca, Romania. cmagdas@usamvcluj.ro
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. May 21, 2015; 21(19): 5823-5830 Published online May 21, 2015. doi: 10.3748/wjg.v21.i19.5823
Contribution of the IL-17/IL-23 axis to the pathogenesis of inflammatory bowel disease
Cristina-Sorina Cătană, Ioana Berindan-Neagoe, Vasile Cozma, Cristian Magdaş, Flaviu Tăbăran, Dan Lucian Dumitraşcu
Cristina-Sorina Cătană, Department of Medical Biochemistry, “Iuliu Haţieganu” University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania
Ioana Berindan-Neagoe, Department of Immunology, “Iuliu Haţieganu” University of Medicine and Pharmacy, 400174 Cluj-Napoca, Romania
Vasile Cozma, Cristian Magdaş, Department of Parasitology and Parasitic Diseases, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania
Flaviu Tăbăran, Department of Morphopathology, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania
Dan Lucian Dumitraşcu, 2nd Medical Department, “Iuliu Haţieganu” University of Medicine and Pharmacy, 400003 Cluj-Napoca, Romania
Author contributions: Cătană CS initiated this review, searched the literature and contributed largely to the writing of the manuscript; Cozma V, Berindan-Neagoe I and Dumitraşcu DL contributed with their own opinions to this review, surveyed and adviced the literature search, offered suggestions on the structure of this paper, contributed to the writing, reviewed all the versions of the manuscript and gave the final approval of the version to be published; Magdaş C and Tăbăran F drafted the article and revised it critically for important intellectual content.
Supported by grants from “Iuliu Haţieganu” University, No. 1495/9/28.01.2014 (to Cristina-Sorina Cătană); and POSDRU project, No. 159/1.5/S/136893, published under the frame of European Social Fund, Human Resources Development Operational Programme 2007-2013 to (Cristian Magdaş).
Conflict-of-interest: None of the authors have conflict of interest in respect to this paper.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Cristian Magdaş, DVM, PhD, Lecturer, Department of Parasitology and Parasitic Diseases, University of Agricultural Sciences and Veterinary Medicine, Calea Mănăştur 3-5, 400372 Cluj-Napoca, Romania. cmagdas@usamvcluj.ro
Telephone: +40-264-596384 Fax: +40-264-593792
Received: October 12, 2014 Peer-review started: October 13, 2014 First decision: November 14, 2014 Revised: December 4, 2014 Accepted: January 21, 2015 Article in press: January 21, 2015 Published online: May 21, 2015 Processing time: 219 Days and 21.2 Hours
Abstract
Inflammatory bowel diseases (IBDs) are chronic disorders of modern society, requiring management strategies aimed at prolonging an active life and establishing the exact etiology and pathogenesis. These idiopathic diseases have environmental, genetic, immunologic, inflammatory, and oxidative stress components. On the one hand, recent advances have shown that abnormal immune reactions against the microorganisms of the intestinal flora are responsible for the inflammation in genetically susceptible individuals. On the other hand, in addition to T helper cell-type (Th) 1 and Th2 immune responses, other subsets of T cells, namely regulatory T cells and Th17 maintained by IL-23 are likely to develop IBD. IL-23 acts on innate immune system members and also facilitates the expansion and maintenance of Th17 cells. The IL-17/IL-23 axis is relevant in IBD pathogenesis both in human and experimental studies. Novel biomarkers of IBD could be calprotectin, microRNAs, and serum proinflammatory cytokines. An efficient strategy for IBD therapy is represented by the combination of IL-17A and IL-17F in acute IL-17A knockout TNBS-induced colitis, and also definite decrease of the inflammatory process in IL-17F knockout, DSS-induced colitis have been observed. Studying the correlation between innate and adaptive immune systems, we hope to obtain a focused review in order to facilitate future approaches aimed at elucidating the immunological mechanisms that control gut inflammation.
Core tip: The pathogenesis of inflammatory bowel diseases (Crohn’s disease and ulcerative colitis) is multifactorial and still not completely understood. There is a need to identify new diagnostic biomarkers as well as an efficient therapy for these diseases. A better understanding of the immunological mechanisms that control gut inflammation, is of high clinical importance because it offers the possibility to develop new drugs, which attack the key pro-inflammatory pathways in chronic intestinal inflammation.
