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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 21, 2015; 21(11): 3245-3255
Published online Mar 21, 2015. doi: 10.3748/wjg.v21.i11.3245
Published online Mar 21, 2015. doi: 10.3748/wjg.v21.i11.3245
MicroRNA-1290 promotes esophageal squamous cell carcinoma cell proliferation and metastasis
Ming Li, Xiao-Yan He, Zhi-Mei Zhang, Shuo Li, Li-Hua Ren, Ri-Sheng Cao, Ya-Dong Feng, Yin-Lin Ji, Ye Zhao, Rui-Hua Shi, Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210009, Jiangsu Province, China
Ming Li, Department of Gastroenterology, Friendliness Hospital of Yangzhou, Yangzhou 225009, Jiangsu Province, China
Zhi-Mei Zhang, Department of Gastroenterology, First People’s Hospital of Lianyunina, Lianyunina 222002, Jiangsu Province, China
Author contributions: Li M designed the research; He XY, Zhang ZM, Li S and Ren LH performed the research; Cao RS and Feng YD collected the clinical data; Ji YL, Shi RH and Zhao Y analyzed the data; and Li M wrote the paper.
Supported by grants from Innovative Team Project of Jiangsu Province , China, No. CXZZ11_0705.
Corresponding author: Rui-Hua Shi, MD, PhD, Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guang Zhou Road, Gulou District, Nanjing 210029, Jiangsu Province. China. ruihuashi@126.com
Received: August 8, 2014
Revised: October 11, 2014
Accepted: December 14, 2014
Published online: March 21, 2015
Processing time: 223 Days and 2.5 Hours
Revised: October 11, 2014
Accepted: December 14, 2014
Published online: March 21, 2015
Processing time: 223 Days and 2.5 Hours
Core Tip
Core Tip: In this study, we reported the clinical significance and biological effects of miR-1290 in esophageal squamous cell carcinoma (ESCC). We found that miR-1290 was significantly up-regulated in ESCC tissues. Moreover, we showed that ectopic expression of miR-1290 significantly promoted ESCC cell growth, migration and invasion. Further investigation revealed that suppressor of cancer cell invasion was a downstream target of miR-1290.