Published online Sep 14, 2022. doi: 10.3748/wjg.v28.i34.5036
Peer-review started: February 7, 2022
First decision: April 10, 2022
Revised: May 1, 2022
Accepted: July 25, 2022
Article in press: July 25, 2022
Published online: September 14, 2022
Severe alcoholic hepatitis (AH) is one of the most lethal manifestations of alcohol-associated liver disease. In light of the increase in alcohol consumption worldwide, the incidence of AH is on the rise, and data examining the trends of AH admission is needed.
To examine inpatient admission trends secondary to AH, along with their clinical outcomes and epidemiological characteristics.
The National Inpatient Sample (NIS) database was utilized, and data from 2011 to 2017 were reviewed. We included individuals aged ≥ 21 years who were admitted with a primary or secondary diagnosis of AH using the International Classification of Diseases (ICD)-9 and its correspondent ICD-10 codes. Hepatitis not related to alcohol was excluded. The national estimates of inpatient admissions were obtained using sample weights provided by the NIS.
AH-related hospitalization demonstrated a significant increase in the USA from 281506 (0.7% of the total admission in 2011) to 324050 (0.9% of the total admi
The number of AH inpatient hospitalizations significantly increased from 2011 to 2017. This could have a substantial financial impact with increasing healthcare costs and utilization. AH-mortality remained the same.
Core tip: This study demonstrated a significant increase in the number of hospitalizations due to alcoholic-associated hepatitis (AH) throughout the USA, with an overall increase in the cost and financial burden of the disease. These trends were in line with the increase in the incidence of alcohol misuse across the years. This study provides potential data for future prospective research to help trigger more aggressive screening and prevention methods for alcohol abuse to prevent AH. Additionally, there is a need for the development of novel therapeutic agents targeting the disease since AH treatment is limited.