Retrospective Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 14, 2022; 28(34): 5036-5046
Published online Sep 14, 2022. doi: 10.3748/wjg.v28.i34.5036
Trends in hospitalization for alcoholic hepatitis from 2011 to 2017: A USA nationwide study
Ali Wakil, Mujtaba Mohamed, Zaid Tafesh, Mumtaz Niazi, Raquel Olivo, Weiyi Xia, Patricia Greenberg, Nikolaos Pyrsopoulos
Ali Wakil, Zaid Tafesh, Mumtaz Niazi, Raquel Olivo, Nikolaos Pyrsopoulos, Department of Gastroenterology and Hepatology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA
Mujtaba Mohamed, Department of Gastroenterology and Hepatology, Marshall University Hospital, Huntington, WV 25701, USA
Weiyi Xia, Patricia Greenberg, Department of Biostatistics & Epidemiology, Rutgers School of Public Health, Piscataway, NJ 08854, USA
Author contributions: Wakil A contributed to the manuscript writing, methodology, editing, project administration; Mohamed M contributed to the manuscript writing and editing; Tafesh, Z, Olivo R and Niazi M contributed to the reviewing and editing; Greenberg P and Xia W contributed to the statistical analysis, data extraction; Pyrsopoulos N contributed to the supervision, reviewing and editing; all authors have read and approved the final manuscript.
Institutional review board statement: This study was done using the NIS database which does not require approval from the IRB, thus no IRB approval was needed for this study.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data using NIS database which contains no identifying patient information and does not require informed consent to use the data.
Conflict-of-interest statement: All authors have no relevant conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Nikolaos Pyrsopoulos, FAASLD, AGAF, FRCP, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology and Hepatology, Rutgers New Jersey Medical School, 185 S. Orange Avenue MSB H Rm - 536, Newark, NJ 07103, United States.
Received: February 7, 2022
Peer-review started: February 7, 2022
First decision: April 10, 2022
Revised: May 1, 2022
Accepted: July 25, 2022
Article in press: July 25, 2022
Published online: September 14, 2022
Research background

Alcoholic hepatitis (AH) is a significant healthcare issue with rising alcohol use in the USA. Alcohol-associated liver disease is the second leading indication for liver transplantation after surpassing chronic hepatitis C infection.

Research motivation

With increasing alcohol consumption there is a need to measure the magnitude of AH effects.

Research objectives

The study aimed to examine the trends in hospitalization of AH patients across the USA. The second aim was to look at the mortality of hospitalized patients, along with the risk factors associated with death while hospitalized.

Research methods

Data were extracted from National Inpatient Sample database using discharge diagnosis codes of International Classification of Diseases (ICD)-9 and their corresponding ICD-10. We included hospitalization for the years from 2011 to 2017.

Research results

AH inpatient hospitalization increased from 0.7% of total admissions to 0.9% of total admissions. Mortality for admitted patients remained the same.

Research conclusions

There has been an increase in AH hospitalization that could affect the healthcare system. Acute renal failure, sepsis and gastrointestinal hemorrhage are highly associated with increased mortality in AH patients.

Research perspectives

New studies should focus on finding new therapeutic targets of AH. New studies should look for improved strategies to limit alcohol misuse.