Retrospective Cohort Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 7, 2017; 23(37): 6877-6883
Published online Oct 7, 2017. doi: 10.3748/wjg.v23.i37.6877
Measurement of biological age may help to assess the risk of colorectal adenoma in screening colonoscopy
Sang-Jung Kim, Beom Jin Kim, Hyun Kang
Sang-Jung Kim, Department of Internal Medicine, Bundang Jesaeng Hospital, Sungnam-si, Gyungki-do 13590, South Korea
Beom Jin Kim, Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul 06973, South Korea
Hyun Kang, Department of Anesthesiology and Pain Medicine, Chung-Ang University College of Medicine, Seoul 06973, South Korea
Author contributions: Kim BJ designed research; Kim BJ and Kim SJ performed research; Kang H analyzed data; Kim SJ wrote the paper.
Institutional review board statement: This study protocol was approved by the Ethics Committees at Bundang Jesaeng Hospital (approval No. IMG 15-04).
Informed consent statement: Informed consent was waived by the IRB because the study used anonymous clinical data.
Conflict-of-interest statement: The authors declare no conflict of interest in this study.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Beom Jin Kim, MD, PhD, Associate Professor, Department of Internal Medicine, Chung-Ang University College of Medicine, 102 Heukseok-ro, Dongjak-gu, Seoul 06973, South Korea.
Telephone: +82-2-62992060 Fax: +82-2-62992064
Received: June 11, 2017
Peer-review started: June 12, 2017
First decision: July 13, 2017
Revised: August 15, 2017
Accepted: September 6, 2017
Article in press: September 5, 2017
Published online: October 7, 2017

To investigate the clinical utility of biological age (BA) measurement in screening colonoscopy for the detection of colorectal adenomas in the average-risk population.


A consecutive series of asymptomatic subjects aged ≥ 30 years who underwent colonoscopy in routine check-ups were enrolled. Colorectal adenoma was classified according to size, number, and location. BAs were calculated using the MEDIAGETM Biological Age Measurement System.


A total of 2696 subjects were investigated (1876 men and 820 women). The mean chronological age (CA) was 46.0 years and the mean BA was 44.7 years. Metabolic syndrome (MS) was diagnosed in 218 subjects (8.1%). The prevalence of overall colorectal adenoma was 23.1% (622/2,696). When the subjects were divided into four groups based on BA (≤ 39 years; 40-49 years; 50-59 years; ≥ 60 years), the prevalence of colorectal adenoma was increased as BA increased (P < 0.001). Colorectal adenoma located in the proximal colon was more prevalent in the BA-dominant group (BA-CA ≥ 5 years) than the CA-dominant group (CA-BA ≥ 5 years) (P = 0.034). When the subjects were categorized into four groups according to MS and age gap between BA and CA, the incidence of colorectal adenoma increased with MS and BA-dominance (P < 0.05).


Measurement of BA may help to assess the risk of colorectal adenoma in screening colonoscopy.

Keywords: Chronological age, Biological age, Colorectal adenoma, Age gap

Core tip: The present study was conducted on the basis of the hypothesis that colorectal adenoma recognized as a premalignant lesion of colorectal cancer is associated with the biological aging process, suggesting that biological age (BA) represents a biological activity in human. Thus, we intended to assess the risk of colorectal adenomas in the average-risk population from the biological perspective. As a result, the present study demonstrated that the prevalence of colorectal adenoma correlated well with BA, and was more common in the distal colon in BA -dominance.