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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Health-related quality of life in patients that have undergone liver resection: A systematic review and meta-analysis
Tomohiro Ishinuki, Shigenori Ota, Kohei Harada, Hiroomi Tatsumi, Keisuke Harada, Koji Miyanishi, Minoru Nagayama, Ichiro Takemasa, Toshio Ohyanagi, Thomas T Hui, Toru Mizuguchi
Tomohiro Ishinuki, Toru Mizuguchi, Department of Nursing, Surgical Sciences, Sapporo Medical University, Sapporo 060-8556, Japan
Shigenori Ota, Minoru Nagayama, Ichiro Takemasa, Departments of Surgery, Surgical Science and Oncology, Sapporo Medical University, Sapporo 060-8543, Japan
Kohei Harada, Division of Radiology, Sapporo Medical University, Sapporo 060-8543, Japan
Hiroomi Tatsumi, Department of Intensive Care Medicine, Sapporo Medical University Hospital, Sapporo 060-8543, Japan
Keisuke Harada, Department of Emergency Medicine, Sapporo Medical University Hospital, Sapporo 060-8543, Japan
Koji Miyanishi, Department of Medical Oncology, Sapporo Medical University Hospital, Sapporo 060-8543, Japan
Toshio Ohyanagi, Department of Liberal Arts and Sciences, Center for Medical Education, Sapporo Medical University, Sapporo 060-8556, Japan
Thomas T Hui, Department of Surgery, Division of Pediatric Surgery, Stanford University School of Medicine, Stanford, CA 94598, United States
Author contributions: Ishinuki T and Ota S conceptualized and designed the systematic review; Ishinuki T and Ohyagangi T searched for and screened the articles; Harada K and Tatsumi H assessed the articles for eligibility; Miyanaishi K and Nagayama M carried out the statistical analyses; Takemasa I supervised and audited the preparation of the manuscript; Hui TT and Mizuguchi T drafted the initial manuscript; Mizuguchi T finalized the manuscript; and all of the authors reviewed and approved the final manuscript as submitted.
Supported by Grant-in-Aid from JSPS KAKENHI, No. JP 20K10404 (to Mizuguchi T); the Hokkaido Hepatitis B Litigation Orange Fund, No. 2059198; Terumo Life Science Foundation, No. 2000666; Pfizer Health Research Foundation, No. 2000777; Daiichi Sankyo Company, No. 2109540; Shionogi and Co., No. 2109493; MSD, No. 2099412; Takeda, No, 2000555; Sapporo Doto Hospital, No. 2039118; Noguchi Hospital, No. 2029083; Doki-kai Tomakomai Hospital, No. 2059203; and Tsuchida Hospital, No. 2069231.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
http://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Toru Mizuguchi, MD, PhD, Professor, Surgeon, Department of Nursing, Surgical Sciences, Sapporo Medical University, S-1, W-16, Chuo-Ku, Sapporo 060-8556, Japan.
tmizu@sapmed.ac.jp
Received: January 22, 2021
Peer-review started: January 22, 2021
First decision: February 10, 2021
Revised: February 10, 2021
Accepted: February 25, 2021
Article in press: February 25, 2021
Published online: February 28, 2021
Processing time: 39 Days and 10.2 Hours
BACKGROUND
Mortality after hepatectomy has decreased, and the quality of various surgical approaches to hepatectomy have been evaluated. Various assessments of quality of life (QOL) after hepatectomy have been developed and investigated in different clinical settings.
AIM
To conduct a systematic review and meta-analysis to examine two clinical topics: Laparoscopic hepatectomy vs open hepatectomy, and preoperative QOL status vs postoperative QOL status.
METHODS
A systematic literature search was performed using PubMed and MEDLINE, including the Cochrane Library Central. The following inclusion criteria were set for inclusion in this meta-analysis: (1) Studies comparing preoperative QOL and postoperative QOL; and (2) Studies comparing QOL between laparoscopic hepatectomy and open hepatectomy.
RESULTS
A total of 8 articles were included in this meta-analysis. QOL was better after laparoscopic hepatectomy than after open hepatectomy.
CONCLUSION
The outcomes of evaluations of QOL after hepatectomy can depend on the type of questionnaire used, the timing of the assessment, and the etiology of the hepatic disease.
Core Tip: A systematic review and meta-analysis of post-hepatectomy quality of life (QOL) assessments were conducted. A total of ten studies were included in the meta-analysis. QOL was better after hepatectomy than after transarterial chemoembolization. QOL was also better after laparoscopic hepatectomy than after open hepatectomy. The outcomes of post-hepatectomy QOL evaluations could depend on the type of questionnaire used, the timing of the assessment, and the etiology of the hepatic disease.
