Review
Copyright ©The Author(s) 2021.
World J Clin Cases. Dec 6, 2021; 9(34): 10400-10417
Published online Dec 6, 2021. doi: 10.12998/wjcc.v9.i34.10400
Table 1 circRNAs involved in gastric cancer gene transcription regulation and drug resistance
Cancer species
circRNA
Gene expression
Mechanism
Drug
Ref.
Up
Down
Gastric cancercircRNA100876Via miR-665/YAP1 signaling pathwayNR[66]
Gastric cancercircCUL3Acts as a sponge for miR-515-5pNR[67]
Gastric cancercircTMEM87AActs as a sponge for miR-142-5pNR[68]
Gastric cancercircRNA0044516Acts as a sponge for miR-149NR[69]
Gastric cancercirc0000039Acts as a sponge for miR-1292-5pNR[70]
Gastric cancerhas-circ-0004872Acts as a sponge for miR-224NR[71]
Gastric cancercirc-ITCHNegative regulation of Wnt/β-catenin signaling pathwayNR[72]
Gastric cancercircPDZD8Acts as a sponge for miR-197-5pNR[73]
Gastric cancercircMTHFD2Combined with miR-124 to exert sponge effect and induce MDR-1 proteinPemetrexed[74]
Gastric cancercirc-PVT1By negatively regulating miR-124-3pPaclitaxel[75]
Gastric cancercircAKT3Promote PIK3R1 expression through miR-198Cisplatin[76]
Gastric cancercircFhashsa-circ-0058147Regulation of cisplatin activity via miR-182-5pCisplatin[77]
Table 2 circRNAs involved in liver cancer gene transcription regulation and drug resistance
Cancer type
circRNA
Gene expression
Mechanism
Drug
Ref.
Up
Down
Liver cancercirc100084Promotes IGF2 expression by acting as a sponge for HSA-MIR-23A-5PNR[81]
Liver cancercircABCB10Upregulates HMG20A expression by acting as a miR-670-3p spongeNR[83]
Liver cancercircRNA-101237Increased levels in serum and Huh7 cells of cisplatin-resistant HCC patientsCisplatin[84]
Liver cancerHsa-circ-u0006294, hsa-circ-u0035944, hsa-circ-u0084663Plays a role by activating the Wnt/β-catenin pathwaySorafenib[85]
Liver cancercirc-0003418Inhibits Wnt/β-catenin pathwayCisplatin[86]
Liver cancercircFBXO11Uses miR-605 /FOXO3/ABCB1 axis adjustmentOxaliplatin[87]
Table 3 circRNAs involved in colon cancer gene transcription regulation and drug resistance
Cancer type
circRNA
Gene expression
Mechanism
Drug
Ref.
Up
Down
Colon cancercircNSUN2Interact with YTHDC1, SRSF3 and NXF1NR[91]
Colon cancerhsa-circ-101555Acts as miR-597-5p spongeNR[92]
Colon cancercircHIPK3Acts as miR-7 spongeNR[93]
Colon cancercircCCDC66DHX9 phosphorylationOxaliplatin[94,95]
Colon cancercirc-001680Adjust BMI1 via miR-340Irinotecan[98]
Colon cancerhsa-circ-0005963Acts as miR-122 spongeOxaliplatin[99]
Colon cancercirc-0000338↑ or ↓Knock out circ-0000338 improves drug resistance5-FU[100]
Colon cancerhsa-circ-32883uncertain5-FU, oxaliplatin[101]
Colon cancercirc0007031, circ0000504, circ0007006Use hsa-miR485-5p pathway5-FU[102]
Colon cancerhsa-circ-0079662Using the TNF-α pathwayoxaliplatin[103]
Colon cancercircDDX17Adjustable via miR-31-5p/KANK1 axis5-FU[104]
Table 4 circRNAs involved in esophageal cancer gene transcription regulation and drug resistance
Cancer type
circRNA
Gene expression
Mechanism
Drug
Ref.
Up
Down
Esophageal cancercircUBAP2Acts as miR-422a spongeNR[108]
Esophageal cancerhsa-circ-0006948miR-490-3p to enhance HMGA2-induced EMTNR[109]
Esophageal cancercirc-0000654miR-149-5p/IL-6/STAT3 pathwayNR[110]
Esophageal cancercircGSK3β-catenin signal passingNR[111]
Esophageal cancercirc-Foxo3miR-23a/PTEN pathwayNR[112]
Esophageal cancercircPVT1Acts as miR-4663 spongeNR[113]
Esophageal cancerciRS-7Acts as a miR-876-5p spongeRapamycin[114,115]
Esophageal cancercircRNA-001275Acts as a miR-370-3p spongeCisplatin[117]
Table 5 circRNAs involved in pancreatic cancer gene transcription regulation and drug resistance
Cancer typecircRNAGene expression
MechanismDrugRef.
Up
Down
Pancreatic cancercircBFARActs as a miR-34b-5p spongeNR[119]
Pancreatic cancercircFOXK2Acts as miR-942 spongeNR[120]
Pancreatic cancercirc-ADAM9Activate ERK/VEGF signaling pathway through miR-217NR[121]
Pancreatic cancercirc-ASH2LActs as a sponge for miR-34aNR[122]
Pancreatic cancercirc-LDLRAD3Adjustable via miR-137-3p/PTN axisNR[123]
Pancreatic cancercirc-0000977Acts as a sponge for miR-153NR[124]
Pancreatic cancerhsa-circRNA-0007334Competitive binding through hsa-miR-144-3pNR[125]
pancreatic cancerciRS-7Acts as miR-7 spongeNR[126]
Pancreatic cancercirc-0030235Acts as miR-1253 and miR-1294 spongeNR[127]
Pancreatic cancercircZMYM2Acts as a miR-335-5p spongeNR[128]
Pancreatic cancercirc-0007534Acts as miR-625, miR-892b spongeNR[129]
Pancreatic cancercirc-IARSActs as miR-122 spongeNR[130]
Pancreatic cancercirc-PDE8AAs a sponge of miR-338 to regulate MACC1NR[131]
Pancreatic cancercircHIPK3Acts as a miR-330-5p spongeGemcitabine[133]