Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 6, 2021; 9(34): 10400-10417
Published online Dec 6, 2021. doi: 10.12998/wjcc.v9.i34.10400
Role of circular RNAs in gastrointestinal tumors and drug resistance
Shi-Jun Xi, Wen-Qi Cai, Qin-Qi Wang, Xiao-Chun Peng
Shi-Jun Xi, Wen-Qi Cai, Qin-Qi Wang, Xiao-Chun Peng, Department of Pathophysiology, School of Basic Medicine, Health Science Center, Yangtze University, Jingzhou 434023, Hubei Province, China
Author contributions: Peng XC designed and supervised the study; Xi SJ reviewed the references; Xi SJ and Peng XC wrote the manuscript; Xi SJ, Cai WQ and Wang QQ contributed to tables and figures.
Supported by Natural Science Foundation of Hubei Province, China, No. 2017CFB786; Hubei Province Health and Family Planning Scientific Research Project, China, No. WJ2016Y10; Jingzhou Science and Technology Bureau Project, China, No. 2017-93; the College Students Innovative Entrepreneurial Training Program in Yangtze University, China, No. 2019376; and Postgraduate Innovation Fund Project of Yangtze University, China, No. 200202.
Conflict-of-interest statement: The authors declared no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Xiao-Chun Peng, PhD, Doctor, Department of Pathophysiology, School of Basic Medicine, Health Science Center, Yangtze University, No. 1 Nanhuan Road, Jingzhou 434023, Hubei Province, China.
Received: February 7, 2021
Peer-review started: February 7, 2021
First decision: March 14, 2021
Revised: March 26, 2021
Accepted: August 5, 2021
Article in press: August 5, 2021
Published online: December 6, 2021
Core Tip

Core Tip: Circular RNAs (circRNAs) were first discovered in 1976, and then more related biological functions were discovered. For example, as a miRNA sponge, circRNA participates in tumor-related processes, translation modification, signal transduction, and DNA damage repair. Gastrointestinal tumors have a high incidence, and some patients also show drug resistance during treatment. On this basis, we reviewed the relationship between circRNA and gastrointestinal tumors and the relevance of drug resistance, hoping to conduct more in-depth research on circRNA. At the same time, it is hoped that circRNA will provide new directions and strategies for future cancer treatment.