Retrospective Study
Copyright ©The Author(s) 2021.
World J Clin Cases. Nov 6, 2021; 9(31): 9431-9439
Published online Nov 6, 2021. doi: 10.12998/wjcc.v9.i31.9431
Table 1 Baseline characteristics of the 1922 subjects involved in the study, n (%)
Age
52.3 ± 9.8
Gender (male)1065 (55.41)
Helicobacter pylori757(39.39)
Gastric cancer10 (0.52)
Table 2 Serum pepsinogen levels in different OLGA groups
OLGA grade
n
PGI (ng/mL)
PGII (ng/mL)
PGR
0159090.4 ± 82.28.3 ± 8.610.1 ± 9.3
I18568.7 ± 71.217.8 ± 8.58.1 ± 5.61
II8873.7 ± 80.719.8 ± 8.87.5 ± 4.61
III4360.8 ± 51.1111.7 ± 12.81,26.7 ± 4.41,2,3
IV652.1 ± 37.3115.5 ± 9.94.1 ± 3.71,2,3
1P < 0.05, compared with the OLGA-0 group.
2P < 0.05, compared with the OLGA-I group.
3P < 0.05, compared with the OLGA-II group.
OLGA: Operative Link for Gastritis Assessment; PG: Pepsinogen; PGR: Pepsinogen I/pepsinogen II ratio.
Table 3 Serum pepsinogen levels in different OLGIM groups
OLGIM grade
n
PGI (ng/mL)
PGII (ng/mL)
PGR
0152291.1 ± 83.88.5 ± 8.99.9 ± 8.8
I25279.2 ± 80.718.1 ± 8.49.0 ± 8.3
II8966.4 ± 76.518.8 ± 7.67.3 ± 6.31,2,3
III4156.3 ± 45.11,29.5 ± 6.726.3 ± 4.11,2,3
IV860.8 ± 26.41,28.6 ± 11.76.7 ± 18.8
1P < 0.05, compared with the OLGIM-0 group.
2P < 0.05, compared with the OLGIM-I group.
3P < 0.05, compared with the OLGIM-II group.
OLGA: Operative Link for Gastritis Assessment; PG: Pepsinogen; PGR: Pepsinogen I/pepsinogen II ratio.
Table 4 Age, sex, and presence of Helicobacter pylori infection in different Operative Link for Gastritis Assessment groups, n (%)
OLGA grade
0
I
II
III
IV
Sex (male)866 (54.5)109 (58.9)57 (64.8)25 (58.1)3 (50.0)
Age51.9 ± 9.954.99 ± 9.1153.49 ± 8.855.42 ± 9.9156.33 ± 8.21
Helicobacter pylori-positive583 (36.7)86 (46.5)151 (60.0)127 (62.8)15 (83.3)1
1P < 0.05, compared with the OLGA-0 group.
OLGA: Operative Link for Gastritis Assessment.
Table 5 Serum pepsinogen levels in the OLGA groups after stratification according to the presence of Helicobacter pylori infection
OLGA-0
I
II
III
IV
Helicobacter pylori-(n = 1007)Helicobacter pylori + (583)Helicobacter pylori - (n = 99Helicobacter pylori+ (n = 86)Helicobacter pylori- (n = 37)Helicobacter pylori+ (n = 51)Helicobacter pylori- (n = 16Helicobacter pylori+ (n = 27)Helicobacter pylori-(n = 1)Helicobacter pylori+ (n = 5)
PGI (ng/mL)82.18 ± 78.64101.70 ± 89.01156.71 ± 66.10273.05 ± 78.201,255.40 ± 54.18292.12 ± 73.51160.00 ± 47.5560.8 ± 54.30234.363.50 ± 43.882
PGII (ng/mL)7.35 ± 6.6110.80 ± 11.3616.60 ± 6.3110.05 ± 10.2317.10 ± 4.8813.00 ± 10.4917.00 ± 6.1313.5 ± 10.6413.816.40 ± 8.70
PGR10.68 ± 8.768.82 ± 9.8918.77 ± 5.0727.24 ± 6.281,27.94 ± 3.5427.18 ± 5.5128.32 ± 3.254.50 ± 3.451,29.0263163.90 ± 2.652
1P < 0.05, within the same pathological subgroup, compared with the Helicobacter pylori- group.
2P < 0.05, within the same Helicobacter pylori subgroup, compared with the OLGA-0 group.
OLGA: Operative Link for Gastritis Assessment; PG: Pepsinogen; PGR: Pepsinogen I/pepsinogen II ratio.