Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 6, 2021; 9(31): 9431-9439
Published online Nov 6, 2021. doi: 10.12998/wjcc.v9.i31.9431
Association of serum pepsinogen with degree of gastric mucosal atrophy in an asymptomatic population
Hao-Lei Cai, Yu-Ling Tong
Hao-Lei Cai, Department of Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China
Yu-Ling Tong, International Healthcare Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China
Author contributions: Cai HL performed the research and wrote the paper; Tong YL designed the research, contributed to the analysis, and supervised the report.
Supported by National Natural Science Foundation of China, No. 71804161 and No. 72074188.
Institutional review board statement: This study was reviewed and approved by the Human Research Ethics Committee of the Second Hospital Affiliated to Zhejiang University School of Medicine (No. 2015-079).
Informed consent statement: All subjects provided written informed consent prior to enrollment in this study.
Conflict-of-interest statement: The authors declare that they have no related financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yu-ling Tong, MD, Doctor, International Healthcare Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, No.88 Jiefang Road, Hangzhou 310009, Zhejiang Province, China. tongyl0313@zju.edu.cn
Received: March 26, 2021
Peer-review started: March 26, 2021
First decision: April 28, 2021
Revised: May 6, 2021
Accepted: September 27, 2021
Article in press: September 27, 2021
Published online: November 6, 2021
Processing time: 216 Days and 22.1 Hours
Core Tip

Core Tip: The current study evaluated the diagnostic value of serum pepsinogen (PG) as a screening marker for atrophic gastritis in asymptomatic healthy check-up populations in different regions of China. Serum PG levels were closely associated with Operative Link for Gastritis Assessment grading and could be used as an effective non-invasive screening tool for atrophic gastritis in asymptomatic subjects. In addition, better results could be obtained in Helicobacter pylori-positive individuals. Screening is more necessary in the elderly, and the application of the aforementioned screening tool may be beneficial for this population.