Biopsy-confirmed fenofibrate-induced severe jaundice: A case report

Table 1 Characteristics of fenofibrate-induced liver injury based on prior case reports

Ref.	Demographic and clinical characteristics				Course of illness			Initial values
	Location	Sex	Age, yr	Daily dose (mg)	Symptoms	Latency	Outcome	ALT(U/L)	ALP(U/L)	Total Bilirubin (mg/dL)	INR
Present case	South Korea	M	65	135 mg	Jaundice, pruritis	6 wk	Recovery, 3 wk	172	1182	15.99	0.92
Ma et al[13], 2019	China	M	65	200 mg	Epigastric discomfort, nausea,fatigue	2 d	Recovery, 2 wk	1136.7	279.7	1.91	NA
Dohmen et al[7], 2005	Japan	F	66	150 mg	Fever, anorexia, hypochondrial discomfort	11 d	Recovery, 2 wk	216	537	1.8	NA
Rigal et al[14], 1989	France	F	74	200 mg	Jaundice	2 yr	Recovery, 2 mo	1430	315	4.6	NA
Ho et al[8], 2004	Taiwan	M	61	300 mg	Jaundice, dark urine, fatigue	2 wk	Recovery, 2 mo	249	259	9.3	NA
Case 1 (Ahmad et al[6], 2017)	Caucasian	M	43	145 mg	Jaundice, dark urine, pale stool, pruritis	6 wk	Recovery	533	440	20.6	1.04
Case 2 (poor prognosis) (Ahmad et al[6], 2017)	Caucasian	M	61	48 mg	Jaundice, rash, pruritis	8 wk	Death (renal failure) at 26 mo	83	518	4.7	1.40
Case 3 (Ahmad et al[6], 2017)	Hispanic	F	37	160 mg	Jaundice, nausea, fatigue, myalgia, abdo pain	5 wk	Recovery	332	344	8.4	0.80
Case 4 (Ahmad et al[6], 2017)	Caucasian	M	43	145 mg	Jaundice, nausea, fatigue, dark urine, pale stool, fever, pruritis	7 wk	Unknown	100	218	5.9	1.00
Case 5 (poor prognosis) (Ahmad et al[6], 2017) Jaward et al. 2017[6]	Caucasian	M	41	160 mg	Jaundice, abdominal pain, nausea	40 wk	Liver Transplant, at 8 mo	78	195	8.0	4.3
Case 6 (Ahmad et al[6], 2017)	Hispanic	M	54	134 mg	Fatigue	56 wk	Recovery	584	106	0.5	NA
Case 7 (Ahmad et al[6], 2017)	Caucasian	F	44	48 mg	Jaundice, dark urine, fatigue	18 wk	Recovery	1197	79	5.1	1.00

M: Male; F: Female; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; INR: International normalized ratio; NA: Not available.