Meta-Analysis
Copyright ©The Author(s) 2021.
World J Clin Cases. Oct 26, 2021; 9(30): 9090-9100
Published online Oct 26, 2021. doi: 10.12998/wjcc.v9.i30.9090
Table 1 Basic characteristics of included studies
Ref.
Year
Country
Sample size
Positive, n (%)
TNM stage
Outcome
Source of HR
NOS score
Rosell et al[18]2007Spain12340 (32.5)IB-IIIAOSR 6
Bartolucci et al[11]2009Italy5436 (66.7)IB-IIBOS/DFSR7
Ma et al[19]2010China8953 (59.6)IIIAOS/DFSE8
Leng et al[20]2012China8514 (16.5)I- IVOS/DFSR7
Gachechiladze et al[21]2013Israel329 (28.1)I- IIOS/DFSE7
Gachechiladze et al[21]2013Israel5815 (25.9)III- IVOS/DFSE7
Yu et al[22]2013China8036 (45)I- IVOS/DFSE7
Grossi et al[23]2015Italy8145 (55.6)I A-IIIBOSR6
Lafuente-Sanchis et al[24]2015Spain6430 (46.9)IDFSR7
Huang et al[12]2016China8411 (13.1)II-IIIDFSR8
Wang et al[25]2017China70NRII-IIIOSR6
Levallet et al[26]2017France221129 (58.4)I- IVOS/DFSR8
Table 2 Correlations of breast cancer susceptibility gene 1 expression with clinicopathological characteristics in resected non-small cell lung cancer
Ref.
Gender (M vs F)
Age (≥ 60 vs < 60)
Tumor size (T3/4 vs T1/2)
TNM stage (III /IV vs I/II)
Histology (AC vs SCC)
Differentiation (poor vs moderate/well)
Rosell et al[18]-----
Bartolucci et al[11]-----
Ma et al[19]1.050 (0.740-1.489)-1.046 (0.734-1.489)-0.916 (0.636-1.319)1.204 (0.860-1.687)
Leng et al[20]------
Gachechiladze et al[21]---0.920 (0.454-1.861)--
Gachechiladze et al[21]0.857 (0.608-1.210)1.273 (0.917-1.768)-1.020 (0.727-1.433)0.990 (0.704-1.392)1.238 (0.890-1.723)
Yu et al[22]------
Grossi et al[23]------
Lafuente-Sanchis et al[24]0.829 (0.265-2.592)0.367 (0.050-2.678)-3.375 (0.776-14.678)1.660 (0.383-7.204)-
Huang et al[12]------
Wang et al[25]0.948 (0.735-1.224)0.889 (0.711-1.112)----
Overall0.94 (0.79-1.12), P = 0.522; I2 = 0.0, P = 0.8711.01 (0.72-1.42), P = 0.948; I2 = 51.2, P = 0.129-1.05 (0.78-1.42), P = 0.739; I2 = 22.7, P = 0.2740.97 (0.76-1.24), P = 0.806; I2 = 0.0, P = 0.7321.22 (0.97-1.55), P = 0.097; I2 = 0.0, P = 0.908
Table 3 Meta-analysis for association of breast cancer susceptibility gene 1 expression with survival of resected esophageal squamous cell carcinoma patients
Analysis
No. of studies
HR (95%CI)
Log-rank P value
I2 (%)
P value
Overall survival 101.60 (1.25-2.05)< 0.00100.794
Country
Non-Asian countries41.57 (1.15-2.15)0.0050.00.798
Asian countries61.66 (1.12-2.45)0.0117.50.495
Disease-free survival91.78 (1.42-2.23)< 0.0010.00.781
Country
Non-Asian countries31.58 (1.13-2.20)0.00722.30.276
Asian countries61.97 (1.44-2.69)< 0.0010.00.936