Serum calcium, albumin, globulin and matrix metalloproteinase-9 levels in acute cerebral infarction patients

Table 1 Univariate analysis of hemorrhagic transformation after intravenous thrombolysis in patients with acute cerebral infarction

Measure	Observation group, n = 40	Control group, n = 460	t/χ2 value	P value
Sex (Male/Female)	23/17	287/173	1.230	0.154
Age in yr (mean ± SD)	76.21 ± 10.33	75.87 ± 10.08	0.922	0.346
History of hypertension (Yes/No)	25/15	249/211	2.221	0.098
History of diabetes (Yes/No)	13/27	142/318	1.255	0.123
History of atrial fibrillation (Yes/No)	14/26	115/345	1.873	0.101
History of cerebrovascular diseases (Yes/No)	11/29	83/377	0.812	0.401
History of smoking (Yes/No)	21/19	253/207	2.437	0.086
History of alcohol consumption (Yes/No)	18/22	193/267	1.167	0.172
NHISS score (mean ± SD)	15.21 ± 2.18	11.42 ± 2.65	17.321	0.001

NHISS: National Institutes of Health Stroke scale; SD: Standard deviation.

Table 2 Comparison of serum calcium, albumin globulin and matrix metalloproteinase-9 between the two groups, mean ± SD

Group	n	Calcium (mmol/L)	Albumin (g/L)	Globulin (g/L)	MMP-9 (ng/mL)
Observation group	40	2.09 ± 0.16	38.58 ± 5.11	29.32 ± 3.45	119.21 ± 12.65
Control group	460	2.29 ± 0.18	47.12 ± 6.43	25.61 ± 4.09	75.64 ± 10.05
t value		4.875	11.243	6.211	19.214
P value		0.043	0.001	0.033	0.001

MMP-9: Matrix metalloproteinase-9; SD: Standard deviation.

Table 3 Multiple logistic regression analysis of hemorrhagic transformation after intravenous thrombolysis in patients with acute cerebral infarction

Parameters	Regression coefficient	Wald test statistic	SD	OR value	P value
NHISS score	0.846	7.643	0.063	1.235	0.014
Calcium	0.758	6.557	0.054	1.322	0.035
Albumin	0.769	7.584	0.087	1.046	0.023
Globulin	0.772	6.810	0.071	1.135	0.033
MMP-9	0.821	7.592	0.063	1.356	0.016

NHISS: National Institutes of Health stroke scale; MMP-9: Matrix metalloproteinase-9; OR: Odds ratio; SD: Standard deviation.