Retrospective Study
Copyright ©The Author(s) 2021.
World J Clin Cases. Oct 26, 2021; 9(30): 9038-9049
Published online Oct 26, 2021. doi: 10.12998/wjcc.v9.i30.9038
Table 1 Baseline patient features and pregnancy outcomes in the whole study population
Characteristics
G-CSF group (n = 242)
Non-G-CSF group (n = 130)
P value
Age (yr), mean ± SD34.23 ± 5.7632.99 ± 5.590.047
BMI (kg/cm2), mean ± SD21.35 ± 3.9720.89 ± 2.630.182
Average infertility years (yr), mean ± SD5.13 ± 1.754.92 ± 1.810.281
Primary infertility cycle, n (%)79 (32.64)53 (40.77)0.118
Secondary infertility cycle, n (%)163 (67.36)77 (59.23)
Average endometrial thickness (mm), mean ± SD7.16 ± 0.407.18 ± 0.430.655
Cycle with one transplanted embryo, n (%)71 (29.34)30 (23.08)0.195
Cycle with two transplanted embryos, n (%)171 (70.66)100 (76.92)
Cycle with blastula transplantation, n (%)97 (40.08)35 (26.92)0.011
Cycle with cleavage stage embryo transplantation, n (%)145 (59.92)95 (73.08)
Clinical pregnancy rate, %46.28 (112/242)51.54 (67/130)0.371
Embryo implantation rate, %35.21 (144/409)35.65 (82/230)0.910
Ectopic pregnancy rate, %2.68 (3/112)1.49 (1/67)> 0.9991
Early abortion rate, %14.29 (16/112)22.39 (15/67)0.166
1Fisher’s exact test. G-CSF: Granular leukocyte-colony stimulating factor; BMI: Body mass index.
Table 2 Baseline patient features and pregnancy outcomes after propensity score matching based on age and blastula/cleavage stage embryo ratio
Characteristics
G-CSF group (n = 122)
Non-G-CSF group (n = 122)
P value
Age (yr), mean ± SD33.54 ± 5.9733.45 ± 5.450.902
BMI (kg/cm2), mean ± SD21.17 ± 2.3320.79 ± 2.710.241
Average infertility years (yr), mean ± SD4.77 ± 1.984.95 ± 1.930.473
Primary infertility cycle, n (%)45 (32.64)50 (40.77)0.512
Secondary infertility cycle, n (%)77 (67.36)72 (59.23)
Average endometrial thickness (mm), mean ± SD7.13 ± 0.437.17 ± 0.430.468
Cycle with one transplanted embryo, n (%)30 (24.59)30 (24.59)> 0.999
Cycle with two transplanted embryos, n (%)92 (75.41)92 (75.41)
Cycle with blastula transplantation, n (%)35 (28.69)35 (28.69)> 0.999
Cycle with cleavage stage embryo transplantation, n (%)87 (71.31)87 (71.31)
Clinical pregnancy rate, %50.82 (62/122)48.3 (59/122)0.701
Embryo implantation rate, %37.38 (80/214)34.11 (73/214)0.480
Ectopic pregnancy rate, %3.23 (2/62)1.69 (1/59)0.965
Early abortion rate, %12.90 (8/62)23.73 (14/59)0.123
G-CSF: Granular leukocyte-colony stimulating factor; BMI: body mass index.
Table 3 Baseline patient features and pregnancy outcomes in cycles with blastula transplantation after propensity score matching based on age and blastula/cleavage stage embryo ratio
Characteristics (blastula)
G-CSF group (n = 35)
Non-G-CSF group (n = 35)
P value
Age (yr), mean ± SD31.26 ± 4.8031.71 ± 4.460.686
BMI (kg/cm2), mean ± SD21.93 ± 2.4121.01 ± 2.650.133
Average infertility years (yr), mean ± SD4.68 ± 1.914.80 ± 1.980.797
Primary infertility cycle, n (%)13 (37.14)16 (45.71)0.467
Secondary infertility cycle, n (%)22(72.86)19(54.29)
Average endometrial thickness (mm), mean ± SD7.10 ± 0.537.07 ± 0.540.815
Cycle with one transplanted embryo, n (%)16 (45.71)14 (40.00)0.233
Cycle with two transplanted embryos, n (%)19 (54.29)21 (60.00)
Clinical pregnancy rate, %68.57 (24/35)57.14 (20/35)0.322
Embryo implantation rate, %57.41 (31/54)44.64 (25/56)0.181
Ectopic pregnancy rate, %4.17 (1/24)0 (0/20)> 0.9991
Early abortion rate, %20.83 (5/24)22.50 (5/20)0.9742
1Fisher’s exact test.
2Corrective Chi-square test. G-CSF: Granular leukocyte-colony stimulating factor; BMI: body mass index.
Table 4 Baseline patient features and pregnancy outcomes in cycles with cleavage stage embryo transplantation after propensity score matching based on age and blastula/cleavage stage embryo ratio
Characteristics (cleavage stage embryo )
G-CSF group (n = 87)
Non-G-CSF group (n = 87)
P value
Age (yr), mean ± SD35.29 ± 6.1834.91 ± 5.670.673
BMI (kg/cm2), mean ± SD20.86 ± 2.2520.70 ± 2.730.674
Average infertility years (yr), mean ± SD4.81 ± 2.135.01 ± 1.900.514
Primary infertility cycle, n (%)32 (36.78)34 (39.08)0.755
Secondary infertility cycle, n (%)55 (63.22)53 (60.92)
Average endometrial thickness (mm), mean ± SD7.17 ± 0.397.26 ± 0.380.125
Cycle with one transplanted embryo, n (%)14 (16.09)16 (18.39)0.161
Cycle with two transplanted embryos, n (%)73 (83.91)71 (81.61)
Clinical pregnancy rate, %43.68 (38/87)44.83 (39/87)0.879
Embryo implantation rate, %30.63 (49/160)30.38 (48/158)0.962
Ectopic pregnancy rate, %2.68 (1/38)1.49 (1/39)> 0.9991
Early abortion rate, %14.29 (3/38)22.39 (9/39)0.066
1Fisher’s exact test. G-CSF: Granular leukocyte-colony stimulating factor; BMI: body mass index.