Copyright
©The Author(s) 2021.
World J Clin Cases. Aug 6, 2021; 9(22): 6403-6409
Published online Aug 6, 2021. doi: 10.12998/wjcc.v9.i22.6403
Published online Aug 6, 2021. doi: 10.12998/wjcc.v9.i22.6403
Reference range | Before treatment | 7 d after treatment | 14 d after treatment | |
Temperature (℃) | 36-37 | Tmax 39.8 | No fever | No fever |
White blood cells (× 109/L) | 3.50-9.50 | 2.88 | 3.78 | 4.33 |
Neutrophils (× 109/L) | 1.8-6.3 | 1.31 | 2.15 | 2.00 |
Hemoglobin (g/L) | 115-150 | 49 | 108 | 93 |
Platelet count (× 109/L) | 125-350 | 50 | 112 | 151 |
Reticulocytes (× 1012/L) | 0.0140-0.0900 | 0.1443 | 0.2269 | 0.0902 |
Indirect bilirubin (μmol/L) | 0.00-12.00 | 15.44 | 16.09 | 8.59 |
Triglyceride (mmol/L) | 0.57-1.70 | 2.45 | 2.42 | 2.23 |
Ferritin (ng/mL) | 11.00-306.00 | 1989.00 | 1730 | 1516 |
Fibrinogen (ng/mL) | 1.70-4.00 | 1.41 | 1.31 | 1.63 |
NK-cell activity | Negative | - | ||
sCD25 (pg/mL) | 21574 | 4775 | ||
Spleen ultrasonography | Length 8.5 ± 1.0 cm | 14.2 | - | |
Thickness 2.8 ± 0.5 cm | 3.8 | 3.4 |
The diagnosis of HLH can be established if either condition 1 or condition 2 below is fulfilled |
(1) A molecular diagnosis consistent with HLH |
(2) Diagnostic criteria for HLH fulfilled (five out of the eight criteria below) |
(A) Initial diagnostic criteria (to be evaluated in all patients with HLH) |
Fever |
Splenomegaly |
Cytopenia (affecting ≥ 2 of 3 lineages in the peripheral blood): |
Hemoglobin < 90 g/L (in infants < 4 wk: hemoglobin < 100 g/L) |
Platelets < 100 × 109/L |
Neutrophils < 1.0 × 109/L |
Hypertriglyceridemia and/or hypofibrinogenemia: |
Fasting triglycerides ≥ 3.0 mmol/L (i.e., ≥ 265 mg/dL) |
Fibrinogen ≤ 1.5 g/L |
Hemophagocytosis in bone marrow or spleen or lymph nodes |
No evidence of malignancy |
(B) New diagnostic criteria |
Low or absent NK-cell activity (according to local laboratory reference) |
Ferritin ≥ 500 µg/L |
Soluble CD25 (i.e., soluble IL-2 receptor) ≥ 2400 U/mL |
- Citation: Zhou X, Duan ML. Malaria-associated secondary hemophagocytic lymphohistiocytosis: A case report. World J Clin Cases 2021; 9(22): 6403-6409
- URL: https://www.wjgnet.com/2307-8960/full/v9/i22/6403.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v9.i22.6403