Meta-Analysis
Copyright ©The Author(s) 2021.
World J Clin Cases. Aug 6, 2021; 9(22): 6357-6379
Published online Aug 6, 2021. doi: 10.12998/wjcc.v9.i22.6357
Table 1 Baseline characteristics of the included studies
Ref.

Study design
Patients (n)
Age (yr) mean ± SD/mean
Gender (M/F)
Clinical T stage
Synchronous/metachronous
Tumor location
Neo chemo
No neo chemo
Neo chemo
No neo chemo
Neo chemo
No neo chemo
Neo chemo
No neo chemo
Allen et al[58], 20032003Retrospective 5254596333/1928/26T1/T2/T3/T452/054/0NR
Tanaka et al[57], 2003 2003Prospective482357 (38-69)59 (37-79)28/2017/6NR33/1518/5a.b
Aloia et al[56], 20062006Retrospective 751757 ± 1260 ± 11.946/298/9NRNRNRNR
Hewes et al[54], 2007 2007Retrospective 8021NRNR40/4011/10NR25/557/14NR
Aloysius et al[55], 2007 2007Prospective792565 (61-72)64 (60-70)49/309/16NRNRNRNR
Mehta et al[53], 20082008Retrospective 13043NRNRNRNRNR51/7917/26NR
Tamandl et al[49], 20092009Retrospective 294175 ± 375 ± 316/1328/13T1/T2/T3/T4NRNRNR
Boostrom et al[52], 20092009Retrospective44556457.528/1630/25NR24/2024/31NR
Lubezky et al[51], 20092009Prospective37196366NRNRNRNRNRa.b
Scoggins et al[50], 20092009Retrospective112745968.567/4538/36T1/T2/T3/T419/939/65a.b.c
Adam et al[48], 20102010Prospective1691302NRNR100/69831/471NRNRNRa.b.c
Scartozzi et al[47], 20112011Prospective6044NRNR23/3723/31T1/T2/T3/T4NRNRNR
Son et al[46], 20112011Retrospective 20206NRNR15/5134/72T1/T2/T3/T412/8126/80a.b
Cucchetti et al[45], 20112011Prospective12511763.9 ±1 0.464.9 ± 9.827/2027/20T1/T2/T3/T419/2819/28NR
Spelt et al[43], 20122012Retrospective9713664 (33-90)66.5 (30-88)61/3681/55T1/T2/T3/T465/9770/66NR
Pinto et al[44], 20122012Retrospective20520558.9 ± 1261.9 ± 12128/77144/61T1/T2/T3/T4123/82105/100NR
Nordlinger et al[59], 20132013RCT 18218260.7 (9.35)62.4 (9.63)127/54114/65T1/T2/T3/T461/12167/115a.b.c
Araujo et al[42], 20132013Retrospective17523654.8 (47.5-62.3)60.9 (51.1-67.6)103/72148/88NRNRNRa.b
Oh et al[41], 20132013Prospective1515546312/311/4T2/T3/T4NRNRa.b
Scilletta et al[40], 20142014Retrospective 5212964 ± 1363 ± 929/2374/55NRNRNRa.b.c
Zhu et al[39], 20142014Retrospective12134558.0 (35-72)59.0 (28-84)81/40213/142T1/T2/T3/T4NRNRa.b
Bonney et al[37], 20152015Retrospective693608NRNR418/275370/238NR693608NR
Schreckenbach et al[36], 2015 2015Retrospective1177161 (35–81)69 (34-85)86/3174/26NR87/3026/45a.
Ayez et al[38], 20152015Retrospective6515463 (58-70)66 (59-72)47/1895/59NR55/10133/21NR
Kim et al[6], 20172017Retrospective 323259 ± 1059 ± 823/922/10T2/T3/T4NRNRa.b.
Strowitzki et al[3], 20172017Prospective125125NRNRNRNRNR69/5669/56a.b.c.
Inoue et al[7], 20182018Retrospective 616166 (33-89)63 (41-85)31/3032/29NR30/3130/31NR
Kumar et al[8], 20182018Prospective17627162 (30-82)63 (29-86)105/71168/103NRNRNRNR
Makowiec et al[9], 20182018Retrospective 10622864 (25-80)64 (33-87)64/42158/70NR68/3894/134a.b
Hirokawa et al[1], 2019 2019Prospective2011767 (28-76)68 (38-89)13/770/47T1/T2/T3/T46/1436/81a.b
Ratti et al[35], 20192019Retrospective 737362 (37-84)60 (35-86)39/3441/32T1/T2/T3/T473/073/0a.b
Wiseman et al[34], 20192019Retrospective 1416141660 ± 761 ± 12836/580803/613NRNRNRNR
Table 2 Meta-analysis results
Outcome indicators
No. of study
Patients (n)
HR/OR/SMD (95%CI)
P value
Heterogeneity
NAC
non-NAC
χ2

P value
5-year overall survival22258042180.49 (0.39-0.61)P < 0.0114.38 0.00%P = 0.853
5-year disease free survival13164328640.48 (0.36-0.63)P < 0.015.680.00%P = 0.931
Duration of surgery8198023960.41 (0.01-0.82)P < 0.05172.7995.90%P = 0.000
Number of liver metastases12101710960.73 (0.02-1.43)P < 0.05549.4698.00%P = 0.000
Blood loss during surgery64746460.53 (-0.05-1.10)P = 0.07290.1294.50%P = 0.000
Length of hospital stay (d)66055650.01 (-0.61-1.02)P = 0.624184.7997.30%P = 0.000
Size of largest metastases (cm)13122615390.03 (-0.31-0.30)P = 0.980168.3992.90%P = 0.000
Synchronous metastases19235525531.17 (0.90-1.58)P = 0.22143.9165.80%P = 0.000
Major liver resection14278031331.06 (0.97-1.22)P = 0.1435.210.00%P = 0.970
Lymph node metastasis16152321281.24 (1.07-1.43)P < 0.0529.2649.50%P = 0.013
R0 liver resection77239760.85 (0.61-1.18)P = 0.3366.294.60%P = 0.391
Perioperative complications17288631611.00 (0.76-1.31)P = 0.98051.8269.10%P = 0.000
Bile leakage10224423641.10 (0.84-1.43)P = 0.4814.770.00%P = 0.782
Surgical site infection8206520560.94 (0.76-1.16)P = 0.5719.6827.70%P = 0.208
Liver failure7202519391.04 (0.76-1.42)P = 0.8135.7713.40%P = 0.329
Blood transfusion5180517101.07 (0.90-1.29)P = 0.4385.9532.80%P = 0.203