Case Report
Copyright ©The Author(s) 2021.
World J Clin Cases. Jul 26, 2021; 9(21): 6102-6109
Published online Jul 26, 2021. doi: 10.12998/wjcc.v9.i21.6102
Table 1 Summary of clinicopathological features of null mismatch repair immunohistochemical staining pattern reported in the literature
Case No.
Age (yr)
Sex
Location
MLH1 promoter methylation status
MSH2 status
BRAF status
Specimen tested
Ref.
172FemaleColorectal cancerHypermethylationGermline G587R mutation NegativeResectionHagen et al[8], 2011
280FemaleColorectal cancerHypermethylationThree somatic mutations (MSH2 c.1861 C>T (p.R621*) in exon 12, c.298G>A (p.V100I) and c.633dupG (p.K212Efs*20) MutationResectionWang et al[9], 2017
376MaleAscending colonHypermethylationUnknownMutationBiopsyWestwood et al[10], 2019