Treatment of leiomyomatosis peritonealis disseminata with goserelin acetate: A case report and review of the literature

Table 1 Timeline of the patient

Event	Date
Hospitalization	January 2018
Laboratory results and Imaging examinations	January 2018
Tamoxifen	January 2018 to July 2018
Goserelin acetate	July 2018 to February 2019
Ulipristal acetate	February 2019 to June 2019
Goserelin acetate	June 2019 to Now

Table 2 Timeline of the surgical history

Date	Surgery procedure	Disease	Number and volume of nodules	Location of fibroids	Pathological examination
December 2007	Abdominal myomectomy	UL	One, diameter 5 cm	Uterine wall	UL
May 2010	Abdominal myomectomy	UL	Two, diameter 8 cm	Uterine wall	UL
June 2012	Abdominal myomectomy and cesarean section	UL, fetal distress	Multiple, the biggest one was 8 cm in diameter	Right uterine wall	UL
April 2015	Total hysterectomy, myomectomy and slapingectomy	Multiple UL	Several nodules, the biggest one was 10 cm in diameter	Uterine wall and peritoneal cavity	Spindle-shaped smooth muscle cell tumor

UL: Uterine leiomyoma.

Table 3 Characteristics of four leiomyomatosis peritonealis disseminata cases treated with goserelin acetate

Case No.	Ref.	Age	Obstetric history	UL history; treatments	OC use/HRT	Symptoms	ER/PR status	Treatments	Response
1	Verguts et al[26], 2014	21	Unknown	Yes; hysteroscopic resection	No/No	Abdominal discomfort	Negative/positive	Goserelin acetate and tibolone × 2 yr → ulipristal acetate × 1 yr	+, +
2	Nassif et al[31], 2016	45	G1P1	Yes; unknown	Yes/No	Dorsal pain	Positive/unknown	Goserelin acetate × 6 mo → Progestin × 6 mo	+, treatment for UL
3	Quaranta et al[19], 2018	60	P3	Yes; unknown	No/No	Abdominal discomfort and postmenopausal bleeding	Strongly positive/strongly positive	Goserelin acetate	LPD recurred within one year
4	Ando et al[24], 2017	40	G0	Yes; transcervical resection	No/No	Abdominal pain	Slightly positive/slightly positive	Goserelin acetate 1.8 mg monthly × 6 mo → TAH, BSO and tumor resection → letrozole	+, LPD recurred 6 mo after surgery, +

OC: Oral contraceptives; HRT: Hormone replacement treatment; TAH: Total abdominal hysterectomy; BSO: Bilateral salpingo-oophorectomy; +: Successful control of leiomyomatosis peritonealis disseminate; LPD: Leiomyomatosis peritonealis disseminate; UL: Uterine leiomyoma; ER: Estrogen receptors; PR: Progesterone receptors.