Rare complication of inflammatory bowel disease-like colitis from glycogen storage disease type 1b and its surgical management: A case report

Table 1 Causes of inflammatory bowel disease-like colitis

Drug-induced[16,17]
Mycophenolic acid
Isotretinoin
Antibiotics
Nonsteroidal antiinflammatory drugs
Oral contraceptives
Etanercept, ipilimumab, and rituximab
Genetic mutations[18,19]
Homozygous variant/mutation in the G6Pase G6PC3 gene
Congenital chloride diarrhoea (SLC26A3 gene mutation)
Primary immunodeficiencies[20,21]
Antibody deficiency (common variable immunodeficiency, severe combined immunodeficiency, agammaglobulinemia, etc.)
Phagocytes defect (G6PC3 deficiency)
Complement deficiency
Immune dysregulation
Immune deficiency + syndromic features
CD4 lymphopenia

G6Pase: Glucose-6-phosphatase.

Table 2 Literature review on surgical management of other inflammatory bowel disease-like colitis

Author, yr	n	Treatment	Results	Discussion
Bolton et al[18], 2020	1	Allogeneic HSCT	HSCT resolves G6PC3-associated immunodeficiency and Crohn’s disease phenotype
Wicker et al[10], 2020	9	G-CSF and cotrimoxazole; polymeric solution enriched in anti-inflammatory cytokine	Modulen IBD®, in addition to G-CSF and anti-bioprophylaxis, improves digestive symptoms	Dietetic treatment improved metabolic balance and clinical symptoms
Norsa et al[19], 2019	12 (2 patients with IBD-like colitis)	ASA; immuno-suppressant and biologics; ileostomy/colectomy	Treatment included a wide range of conservative treatment and ileostomy with variable success
Xiao[9], 2019	2	PEN, mesalazine, and recombinant human G-CSF	G-CSF increased ANC and improved clinical symptoms	G-CSF lowered the risk of developing IBD-colitis
Akkelle et al[20], 2018	425 (195 with GI symptoms)	Conventional immunosuppressive treatment, hematopoietic stem cell transplantation, hemicolectomy	Twelve patients (aged 9-16) had immunodeficiency associated IBD-like colitis.	Surgery was indicated if immune-therapy failed
de Andrade et al[17], 2014	16	MPA switch, reduction, or discontinuation	IIBD-like colitis found in 25% of patients on MPA who underwent colonoscopy	Symptoms resolved after MPA switch or adjustment without need for surgery
Dubeau, et al[16], 2013			Drugs including isotretinoin, antibiotics, nonsteroidal anti-inflammatory drugs may predispose IBD or IBD-like colitis	Pathogenic mechanisms may include altered immune response or microbiota
Kamdar et al[21], 2011	1	Steroids and enteral feeding	Primarily conservative treatment usually sufficient without need for surgery

HSCT: Hematopoietic stem cell transplant; ASA: Amino salicylate acid; PEN: Partial enteral nutrition; G-CSF: Granulocyte colony-stimulating factor; MPA: Mycophenolate; IBD: Inflammatory bowel disease.