Liver injury associated with the use of selective androgen receptor modulators and post-cycle therapy: Two case reports and literature review

Table 1 Summary of the relevant serum laboratory parameters in patients with ligandrol/ostarine and post-cycle therapy use: On admission, after 7 d, and 3 mo

	Normal range	On admission	7 d	3 mo
Case 1, man, 19 yr
Total bilirubin, µmol/L	3.4-17.1	238	221	12
Conjugated bilirubin, µmol/L	0-5	197	184
Alanine aminotransferase, µkat/L	0.2-0.8	2.21	1.57	0.38
Alkaline phosphatase, µkat/L	0.67-2.15	1.54	1.37	1.2
Total bile acids, µmol/L	2-10	299	226	8.6
Serum creatinine, µmol/L	62-106	113.8	113.3
INR	0.8-1.2	0.98	0.98
Case 2, man, 28 yr
Total bilirubin, µmol/L	5.1-19	401	394	25.1
Conjugated bilirubin, µmol/L	0.8-5.1	244	238	4.6
Alanine aminotransferase, µkat/L	0.0-0.8	2.42	1.74	1.6
Alkaline phosphatase, µkat/L	0.5-2.0	1.54	2.19	1.56
INR	0.8-1.2	1.07	0.93	0.96
Serum creatinine, µmol/L	64-104	90	87	80

INR: International normalized ratio.