Pure large cell neuroendocrine carcinoma originating from the endometrium: A case report

Table 1 Published reports of pure endometrial large cell neuroendocrine carcinoma

Case	Ref.	Age in yr	Presenting symptom	Histology	Immunoprofile positivity	FIGO stage	Surgery	Treatment	Outcome
1	Nguyen et al[9]	70	PMB	Pure LCNEC	Synaptophysin, chromogranin A, CD56, EMA	IVB	TAH, BSO, OMT	Etoposide, cisplatin	NED 6 mo
2	Nguyen et al[9]	71	PMB	Pure LCNEC	Synaptophysin, chromogranin A, CD56, P53, P16，PR	IVB	TAH, BSO, LND, OMT	Etoposide, cisplatin, octreotide	DOD 1 mo
3	Nguyen et al[9]	52	PMB	Pure LCNEC	NSE, synaptophysin	IC	TAH, BSO	Etoposide, cisplatin	DOD 7 mo
4	Kobayashi et al[10]	52	Abdominal pain	Pure LCNEC	Synaptophysin, chromogranin A, CD56	IIIC	TAH, BSO, LND	Irinotecan, cisplatin, RT	DOD 10 mo
5	Makihara et al[28]	73	Abdominal distension	Pure LCNEC	Synaptophysin, chromogranin A, NSE, P53	IVB	Refused surgery	Refused chemotherapy	DOD 5 wk
6	Makihara et al[28]	73	PMB	Pure LCNEC	Synaptophysin, chromogranin A, CD56, P53	IIIC	TAH, BSO, LND, OMT	Cisplatin, irinotecan	Recurrence at 6 mo
7	Ogura et al[29]	52	Menorrhagia	Pure LCNEC	Synaptophysin, CD56, Ki67	IIIC	None	None	DOD 1 mo
8	Mulvany et al[27]	50	PMB	Pure LCNEC	NSE, synaptophysin	IIIC	TAH, BSO, LND, OMT	Carboplatin, etoposide, RT	AWD 12 mo
9	Tu et al[15]	51	PMB	Pure LCNEC	CK, P53, CD56, synaptophysin	IVB	TAH, BSO, OMT, suboptimal debulking	Cisplatin, etoposide	DOD 3 mo
10	Shahabi et al[3]	59	PMB	Pure LCNEC	NSE, chromogranin A, synaptophysin, CD56	IIIC	TAH, BSO, LND, OMT, suboptimal debulking	Carboplatin, paclitaxel, doxorubicin, etoposide, cisplatin, octreotide	DOD 12 mo
11	Suh et al[22]	61	Abdominal pain and rapid uterine enlargement	Pure LCNEC	synaptophysin, CD56	IIIB	TAH, BSO, OMT	Etoposide/cisplatin, irinotecan/cisplatin, fluorouracil, leucovorin, irinotecan, RT	DOD 23 mo
12	Present case	73	PMB	Pure LCNEC	Cytokeratin AE1/AE3, chromogranin A, synaptophysin, CD56, P16	IIIC	TAH, BSO	Paclitaxel, liposome, carboplatin	NED 15 mo

AWD: Alive with disease; BSO: Bilateral salpingo-oophorectomy; DOD: Died of disease; FIGO: International Federation of Gynecology and Obstetrics; LCNEC: Large cell neuroendocrine carcinoma; LND: Lymph node dissection; NED: No evidence of disease; NSE: Neural-specific enolase; OMT: Omentectomy; PMB: Postmenopausal bleeding; PR: Progesterone receptor; RT: Radiotherapy; TAH: Total abdominal hysterectomy.