Bronchial glomus tumor with calcification: A case report

Table 1 Clinical and pathological data of the patient

Project	Content
Biographical data	33-yr-old man
Family history	No
Personal or family history	No
Chief complaint	Cough and sputum for 11 d and hemoptysis for 5 d
Physical examination of the lung	Normal except for vesicular breath sounds
Chest computed tomography	1.20 cm × 0.88 cm calcified nodular lesion was found on the compressed posterior wall of the lower left main bronchus (Figure 1). Bronchiectasis in the lower lobe of the left lung was found.
Fiberoptic bronchoscopy	Yellow–white, slightly hard mass was found obstructing the entrance to the basal segment of the lower left lobe (Figure 2). Neoplasms with multiple nodular ridges and superficial hyperemia were observed in the lateral to the entrance of the basal segment of the lower left lobe (Figure 2). Mucosal biopsy using a fiberoptic bronchoscopy is prone to bleeding.
Pathology	Microscopically, the tumor cells were uniformly round with smooth nuclear contours, fine chromatin and a modest amount of pink cytoplasm. They were arranged in sheet-like patterns between small blood vessels (Figure 3A). Left main bronchial glomus tumor with immunohistochemistry results of SMA(+) (Figure 3B) and actin(+) (Figure 3C), CD56 (NK-1)(-), CgA(-), CK5/6(-), CK7(-), napsin-A(-), P40(-), TTF-1(-), CK(-), NSE(-), S-100(-) and Ki-67 (< 1%), and Syn immunohistochemical staining was weakly positive.
Final diagnosis	Bronchial glomus tumor and bronchiectasis
Treatment	Conservative treatment. Piperacillin–tazobactam 4.5 g twice daily and erdosteine 0.3 g twice daily for 9 d. Intravenous administration of Agkistrodon 2 U once.
Follow-up	Clinical follow-up for 25 mo showed that the patient had no symptoms.

SMA: Smooth muscle actin; CgA: Chromogranin A; CK5/6: Cytokeratin5/6; CK7: Cytokeratin7; TTF-1: Thyroid transcription factor-1; CK: Cytokeratin; NSE: Neuron specific enolase; Syn: Synaptophysin.