Systematic Reviews
Copyright ©The Author(s) 2021.
World J Clin Cases. May 16, 2021; 9(14): 3294-3307
Published online May 16, 2021. doi: 10.12998/wjcc.v9.i14.3294
Table 1 Cases of secondary cluster headache associated with vascular pathologies.
YearRef.PathologiesAge at onset, interval between age at onset and diagnosis, yrSex
1997Rosebraugh et al[33]ICAD34Male
2003Frigerio et al[34]ICAD50Female
2005Hannerz et al[16]ICAD58Male
2006Razvi et al[35]ICAD (in the petrous segment of ICA)44Male
2007Hardmeier et al[36]ICAD (petrous segment)38Male
2007Straube et al[13] (case 2)ICAD (cavernous segment)35Male
2008Rigamonti et al[37] (cases 1 and 2)ICAD (case 1, lacerum segment)50Male
ICAD (case 2, lacerum segment)49Male
2008Godeiro-Junior et al[38]ICAD (petrous segment)53Male
2008Tobin et al[39]ICAD (cervical segment)55Male
2013Tsivgoulis et al[40]ICAD (petrous segment)32Male
1991West et al[17]Aneurysm (posterior inferior cerebellar artery, vertebral artery)39 (12)Male
2000McBeath et al[31]Aneurysm (posterior communicating artery)45 (10)Male
2006Gentile et al[11]Aneurysm (multiple cerebral aneurysms)58Female
2007Valença et al[41] (cases 1 and 2)Aneurysm (case 1, posterior communicating artery)47Male
Aneurysm (case 2, intracranial ICA)57Male
2009Sewell et al[42]Aneurysm (moyamoya disease)18 (16)Male
2006Georgiadis et al[25]CVT (superior sagittal sinus)46Male
2006Park et al[26]CVT (right transverse sinus, straight sinus)20 (6)Male
2006Peterlin et al[8]CVT (case 1, left transverse, sigmoid sinus)38 (9)Male
CVT (case 2, left transverse sinus, sigmoid sinus, internal jugular vein)32 (10)Male
2008Rodríguez et al[18]CVT (superior sagittal sinus and bilateral transversal sinuses)51Male
1982Mani et al[43]Arteriovenous malformation (occipital lobe)22 (14)Female
1996Muñoz et al[19]Arteriovenous malformation (case 1, temporal lobe)52Male
Arteriovenous malformation (case 2, frontal lobe)40 (6)Male
2001Piovesan et al[44]Subclavian steal phenomenon51 (9)Female
2008Kim et al[45]Vertebral artery dissection (posterior inferior cerebellar artery)48Female
2008Ashkenazi et al[20]Intra-cavernous carotid artery thrombosis62Male
2017Chang et al[46]Middle meningeal artery dural arteriovenous fistulas42Male
Table 2 Cases of secondary cluster headache associated with tumoural pathologies (including tumours and cysts)
YearRef.PathologiesAge at onset (Interval between age at onset and diagnosis, yr)Sex
1988Greve et al[47] (case 3)Prolactinoma57 (1)Male
2001Porta-Etessam et al[48]Prolactinoma28 (8)Male
2004Leone et al[9]Prolactinoma46 (3)Male
2005Negoro et al[27]Prolactinoma14 (3)Male
2012Levy et al[49]Prolactinoma25Male
2013Edvardsson et al[50]Prolactinoma46Male
2017Andereggen et al[51]Prolactinoma46Male
2017Pineyro et al[52]Prolactinoma15 (3)Female
1991Levyman et al[53]Epidermoid cyst (posterior fossa)40 (13)Female
2006Massie et al[10]Epidermoid cyst (epidermoid clival lesion)36 (3)Male
2007Eimil-Ortiz et al[28]Epidermoid cyst (pontocerebellar angle)47Male
1989Hannerz et al[21]Parasellar meningioma28 (18)Male
1995Taub et al[6]Meningioma (tentorium cerebelli)35-40 (20-25)Male
2003Bigal et al[7]Inflammatory myofibroblastic tumour (undersurface of the tentorium)18.5 (9.5)Male
2008Alty et al[54]Trigeminal meningioma (cerebellopontine angle)30Male
2009Robbins et al[55]Meningioma (planum sphenoidale)29 (8)Male
2012Edvardsson et al[22]Parietal glioblastoma multiforme41Male
2013Edvardsson et al[56]Supra- and intrasellar arachnoid cyst43Male
1982Tfelt-Hansen et al[57]Pituitary chromophobe adenoma21 (31)Male
2014Edvardsson et al[58]Pituitary chromophobe adenoma49Male
1996Milos et al[59]Pituitary GH-producing adenoma33 (4)Male
2016De Pue et al[32]Pituitary cyst35 (12)Male
2004Seijo-Martinez et al[12]Arnold–Chiari type I malformation, syringomyelia36Female
2015Kao et al[60]Arnold–Chiari type I malformation26Male
2014Malissart et al[61]Carotid paraganglioma60Female
Table 3 Cases of secondary cluster headache associated with inflammatory pathologies and idiopathic intracranial hypertension
YearRef.PathologiesAge at onset (Interval between age at onset and diagnosis, yr)Sex
1988Takeshima et al[62]Sinusitis (case1, frontal, ethmoidal, maxillary sinusitis)31Male
Sinusitis (case 2, frontal, maxillary sinusitis)31 (9)Male
1995Zanchin et al[14]Sinusitis (sphenoid sinus aspergillus infection)64Female
1997Heidegger et al[63]Sinusitis (sphenoid sinus aspergillus infection)68Male
2002Scorticati et al[23]Sinusitis (foreign body in the maxillary sinus, maxillary sinusitis)26 (8)Female
2013Edvardsson et al[64]Sisitis (maxillary sinusitis)24Male
2013Edvardsson et al[65]Sinusitis (maxillary sinusitis)21Male
2018Balgetir et al[66] (cases 1-7)Sinusitis (frontal, ethmoid, maxillary sinusitis)23Male
Sinusitis (frontal, maxillary sinusitis)28Male
Frontoethmoidal mucocele33Male
Sinusitis (frontal, ethmoid, maxillary sinusitis)27Male
Sinusitis (maxillary, ethmoid sinusitis)16Male
Sinusitis (frontal sinusitis)31Male
Sinusitis (sphenoid and ethmoid sinusitis) 39Female
2018Branco et al[67]Sphenoid sinus mucocele62Male
2007Harley et al[68]Inflammatory orbital pseudotumour33Female
2009Choi et al[69]Posterior scleritis42 (10)Female
2017Ersoy et al[70]Idiopathic orbital myositis34Female
2019Douglas et al[71]Idiopathic orbital myositis19Female
2007Favier et al[15]Hypothalamus-pituitary granuloma26Female
2013van der Vlist et al[72]Hypothalamus-pituitary granuloma31Male
2006Volcy et al[73]Idiopathic intracranial hypertension40Male
2008Testa et al[74]Idiopathic intracranial hypertension28Female
Table 4 Demographic profile and characters of the headache

Number (%)/mean ± range
Age at onset (n = 66)
Average age38.3 ± 13.0
20-40 yr40 (51.9%)
< 20 yr6 (7.8%)
> 40 yr31 (40.3%)
Sex
Male60 (77.9%)
Female17 (22.1%)
Side
Left43 (55.8%)
Right34 (44.2%)
Sides of headache and structural pathologies (n = 66)
Ipsilateral61 (79.5%)
Midline10 (13.0%)
Contralateral4 (5.2%)
Unknown2 (2.6%)
Attacks not fulfilling ICHD-3
Duration (n = 65)17 (23.3%)
Frequency (n = 57)5 (7.7%)
Headache sites
Orbital/periorbital47 (61.0%)
Temporal23 (30.0%)
Supraorbital16 (20.1%)
Eye/retroorbital26 (33.8%)
Other14 (18.2%)
Associated autonomic symptoms
Lacrimation/conjunctival injection/rhinorrhoea73 (94.5%)
Miosis/ptosis40 (51.2%)
Nasal congestion/eyelid oedema/forehead sweating39 (50.6%)
Nausea/phonophobia/vomiting13 (16.9%)
Persistent miosis/ptosis11 (14.3%)
Additional headaches between attacks18 (23.4%)
Altered neurological examination21 (27.2%)
Table 5 Cluster-like headache patients' responses to typical cluster headache treatments

Effectivenessa (n, %)
Acute treatment
Triptans 19/28 (67.9%)
Oxygen inhalation13/24 (54.2%)
Ergotamine/ergometrine6/20 (30%)
NSAIDs7/31 (22.6%)
Analgesics6/8 (75%)
Caffeine2/2 (100%)
Total53/113 (46.9%)
Preventive treatment
Verapamil 9/17 (52.9%)
Glucocorticoid drugs 11/15 (73.3%)
Propranolol 1/6 (16.7%)
Antipsychotics2/11 (18.2%)
AEDs0/13 (0)
Lithium carbonate1/1
Other antihypertensive drugs 0/2 (0)
Antihistamine0/2 (0)
Total24/67 (35.8%)