Copyright
©The Author(s) 2021.
World J Clin Cases. Apr 26, 2021; 9(12): 2763-2777
Published online Apr 26, 2021. doi: 10.12998/wjcc.v9.i12.2763
Published online Apr 26, 2021. doi: 10.12998/wjcc.v9.i12.2763
Table 1 Studies considering proton pump inhibitors use in patients with severe acute respiratory syndrome coronavirus 2
| Ref. | Type of study | Number of patients with SARS-CoV-2 | Period of intake of PPIs | Number of patients treated or not treated with PPIs (%) | Severity of patients treated or not treated with PPIs (%) | Mortality in patients treated or not treated with PPIs (%) |
| Luxenburger et al[31] | Retrospective | 152 | Home drug | 62 (40.7) | 18 + 11 = 29 (32.2) (secondary infection + ARDS) | 5 (5.6) |
| Luxenburger et al[31] | Retrospective | 152 | Home drug | 90 (59.3) | 30 + 17 = 47 (75.8) (secondary infection + ARDS) | 12 (19.4) |
| Almario et al[32] | Online survey | 3386 | Home drugs | 2661 (78.6) | NA | NA |
| Almario et al[32] | Online survey | 3386 | Home drugs | 752 (2.1) | NA | NA |
| McKeigue et al[48] | Case-control | 36391 | Home drug | 13982 (38.4) | 1177 (8.4) (severe outcomes) | NA |
| McKeigue et al[48] | Case-control | 36391 | Home drug | 22409 (61.6) | 12805 (57.1) (severe outcomes) | NA |
| Argenziano et al[49] | Retrospective | 1000 | Home drug | 163 (16.3) | 38 (23.3) (intensive care units) | NA |
| Argenziano et al[49] | Retrospective | 1000 | Home drug | 837 (83.7) | NA | NA |
| Ramachandran et al[50] | Retrospective | 295 | Home drug | 46 (15.5) | 16 + 12 = 28 (60.8) (shock + mechanical ventilation) | 16 (34.7) |
| Ramachandran et al[50] | Retrospective | 295 | Home drug | 249 (84.5) | 77 + 37 = 114 (45.7) (shock + mechanical ventilation) | 40 (16.1) |
| Lee et al[51] | Retrospective | 534 | Home drug | 267 (50) | 49 | 24 |
| Lee et al[51] | Retrospective | 534 | Home drug | 267 (50) | 32 | 14 |
| Ullah et al[52] | Retrospective | 212 (with pre-existing HPB condition) | Home drug | 109 (51.4) | NA | 27 (24.8) |
| Ullah et al[52] | Retrospective | 212 (with pre-existing HPB condition) | Home drug | 103 (48.6) | NA | 27 (26.2) |
| García-Menaya et al[55] | Retrospective | 113 (asthma and allergic patients) | Home drug | 54 (47.8) | NA | NA |
| García-Menaya et al[55] | Retrospective | 113 (asthma and allergic patients) | Home drug | 59 (52.2) | NA | NA |
| Gadiparthi et al[56] | Retrospective | 3 (all with GI bleeding) | In hospital | 3 (100) | 1 (33.3) (intensive care unit) | 2 (66.7) |
- Citation: Zippi M, Fiorino S, Budriesi R, Micucci M, Corazza I, Pica R, de Biase D, Gallo CG, Hong W. Paradoxical relationship between proton pump inhibitors and COVID-19: A systematic review and meta-analysis. World J Clin Cases 2021; 9(12): 2763-2777
- URL: https://www.wjgnet.com/2307-8960/full/v9/i12/2763.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v9.i12.2763