Sclerosing angiomatoid nodular transformation of the spleen: A case report and literature review

Table 1 Clinical features of sclerosing angiomatoid nodular transformation reported in the literature

Ref.	n	Mean age, yr	Gender, F/M	Clinical features (n cases)	Recurrence
Martel et al[1]	25	48	17/8	Incidental finding on physical examination (14); Abdominal discomfort (6); Splenomegaly (4); Fever (1);	No
Diebold et al[10]	16	44	9/7	Incidental finding on physical examination (7); Splenomegaly with anemia (5); Abdominal pain (2); Fever (2)	No
Hou et al[11]	10	42	8/2	Incidental finding on physical examination (8); Abdominal pain (1); Upper left abdominal pain (1)	No
Nomura et al[12]	71	46	27/44	Incidental finding on imaging studies (33); Abdominal or back discomfort, weight loss, fever (27); Not described (11)	NA
Pelizzo et al[13]	1	9 wk	1/0	Severe abdominal distension and rectal bleeding (1)	No
Liao et al[14]	1	50	1/0	Persistent neutrophilia and unintentional weight loss (1)	No
Sánchez Belmar et al[15]	1	42	0/1	Vomiting and headaches and intravenous drug user (1)	No
Jin et al[16]	37	45	16/19	Incidental finding on imaging studies (35); Fever and leukocytosis (1); Abdominal pain (1)	NA
Chikhladze et al[17]	2	45	1/1	Lasting feeling of abdominal fullness (1); Weight loss and recurring vomiting (1)	No

All cases treated by splenectomy. NA: Information not available.

Table 2 Radiological characteristics of sclerosing angiomatoid nodular transformation reported in the literature

Previous reports	Radiological characteristics
Li et al[8]	Low density with small calcification on plain CT scan and progressive enhancement of the lesion after enhancement
Zeeb et al[18]	Edge enhancement in arterial and portal phases. A stellate low-density region can be seen in the center of the delayed phase of the lesion
Thacker et al[19]	Persistent stellate low-density areas can be seen in the center of the lesion
Bamboat et al[20]	MRI T2-WI showed that the center of the lesion was stellate and low-density, and it appeared as a spoked-wheel configuration
Karaosmanoglu et al[21]	MRI and CT enhancement patterns of marginal enhancement and progressive spoked-wheel enhancement towards the center of the lesion
Nomura et al[12]	CT: Lesion is well circumscribed and of lower attenuation compared to the background spleen, and the mass becomes isodense in the delayed phase.MRI: On fat-saturated precontrast T1-weighted images SANT presented as a central hyperintense area consistent with hemorrhage, and on T2-weighted images, the lesion appeared as a spoke and wheel pattern.

SANT: Sclerosing angiomatoid nodular transformation; CT: Computed tomography; MRI: Magnetic resonance imaging.