Xiong JH, Liu J, Chen J. Clinical significance and prognostic value of tumor necrosis factor-α and dickkopf related protein-1 in ankylosing spondylitis. World J Clin Cases 2020; 8(7): 1213-1222 [PMID: 32337195 DOI: 10.12998/wjcc.v8.i7.1213]
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Table 2 Diagnostic value of dickkopf-related protein-1 and tumor necrosis factor-α in ankylosing spondylitis by receiver operating characteristic curve
DKK-1
TNF-α
Combination
AUC
0.752
0.904
0.934
95%CI
0.684-0.820
0.859-0.950
0.900-0.967
Cutoff value
87.02 pg/mL
18.79 ng/L
Sensitivity
78.76%
79.65%
82.30%
Specificity
66.00%
95.00%
97.00%
Table 3 Predictive value of dickkopf-related protein-1 and tumor necrosis factor-α on the curative effect in ankylosing spondylitis by receiver operating characteristic curve
DKK-1
TNF-α
AUC
0.825
0.863
95%CI
0.749-0.901
0.794-0.932
Cutoff value
68.42 pg/mL
32.79 ng/L
Sensitivity
73.68%
92.11%
Specificity
80.00%
77.33%
Table 4 Multivariate analysis of recurrence of ankylosing spondylitis
B
SE
Wald
df
Sig.
Exp (B)
95%CI
Lower part
Upper part
TNF-α
-0.450
0.362
1.549
1
0.013
0.637
0.314
1.296
CRP
3.871
2.473
2.450
1
0.018
47.992
0.377
61.152
IgG
0.162
0.089
3.325
1
0.168
1.176
0.988
1.445
HLA-B27
-13.651
139.432
0.010
1
0.062
1.325
0.745
3.306
BASDAI
0.305
0.094
10.524
1
0.001
1.357
1.128
1.631
BASMI
-0.063
0.071
0.79
1
0.074
0.939
0.816
1.079
DKK-1
0.020
0.008
6.877
1
0.009
1.021
1.005
1.036
Citation: Xiong JH, Liu J, Chen J. Clinical significance and prognostic value of tumor necrosis factor-α and dickkopf related protein-1 in ankylosing spondylitis. World J Clin Cases 2020; 8(7): 1213-1222