Case Control Study
Copyright ©The Author(s) 2020.
World J Clin Cases. Apr 6, 2020; 8(7): 1213-1222
Published online Apr 6, 2020. doi: 10.12998/wjcc.v8.i7.1213
Table 1 General information
Study group (n = 113)Control group (n = 100)P value
Sex, n (%)0.159
Male76 (67.26)76 (76.00)
Female37 (32.74)24 (24.00)
Age (yr)36.7 ± 4.137.3 ± 4.60.315
BMI (kg/m2)22.25 ± 1.8323.49 ± 2.160.381
Course of disease (yr)1.5 ± 0.4
CRP (ng/L)
Before treatment8.61 ± 0.720.50 ± 0.00< 0.001
After treatment1.32 ± 0.121
IgG (g/L)
Before treatment16.00 ± 1.75
After treatment2.89 ± 0.451
IgA (g/L)
Before treatment4.88 ± 0.91
After treatment0.82 ± 0.211
IgM (g/L)
Before treatment1.49 ± 0.48
After treatment0.24 ± 0.081
Rheumatoid factor(-)
HLA-B27 (+), n (%)
Before treatment85 (75.00)0 (0.00)< 0.001
After treatment15 (13.27)1
ESR (mm/h)
Before treatment48.83 ± 7.7912.29 ± 2.73< 0.001
After treatment28.14 ± 4.321
BASDAI
Before treatment4.98 ± 1.61
After treatment0.93 ± 0.241
BASMI
Before treatment4.26 ± 1.96
After treatment0.71 ± 0.311
Table 2 Diagnostic value of dickkopf-related protein-1 and tumor necrosis factor-α in ankylosing spondylitis by receiver operating characteristic curve
DKK-1TNF-αCombination
AUC0.7520.9040.934
95%CI0.684-0.8200.859-0.9500.900-0.967
Cutoff value87.02 pg/mL18.79 ng/L
Sensitivity78.76%79.65%82.30%
Specificity66.00%95.00%97.00%
Table 3 Predictive value of dickkopf-related protein-1 and tumor necrosis factor-α on the curative effect in ankylosing spondylitis by receiver operating characteristic curve
DKK-1TNF-α
AUC0.8250.863
95%CI0.749-0.9010.794-0.932
Cutoff value68.42 pg/mL32.79 ng/L
Sensitivity73.68%92.11%
Specificity80.00%77.33%
Table 4 Multivariate analysis of recurrence of ankylosing spondylitis
BSEWalddfSig.Exp (B)95%CI
Lower partUpper part
TNF-α-0.4500.3621.54910.0130.6370.3141.296
CRP3.8712.4732.45010.01847.9920.37761.152
IgG0.1620.0893.32510.1681.1760.9881.445
HLA-B27-13.651139.4320.01010.0621.3250.7453.306
BASDAI0.3050.09410.52410.0011.3571.1281.631
BASMI-0.0630.0710.7910.0740.9390.8161.079
DKK-10.0200.0086.87710.0091.0211.0051.036