Laparoscopic surgery for early gallbladder carcinoma: A systematic review and meta-analysis

Table 1 Characteristics of the included comparative studies

Ref.	Year	Country	Intervention	Study type	Study period	Propensity-matched	Quality Score
Jang et al[33]	2019	South Korea	Laparoscopic surgery vs Open surgery	Retro	2004-2017	No	7
Feng et al[32]	2019	China		Retro	2008-2017	No	7
Jang et al[31]	2016	South Korea		Retro	2000-2014	Yes	7
Itano et al[30]	2015	Japan		Retro	2007-2013	No	7
Agarwal et al[13]	2015	India		Retro	2011-2013	No	7
Ha et al[34]	2014	South Korea		Retro	1996-2009	No	6
Goetze et al[29]	2013	Germany		Retro	NA	No	7

Retro: Retrospective study; NA: Not available.

Table 2 Detailed information including T stage of tumor, survival rate, and recurrence in the included comparative studies

Ref.	Year	Country	Comparison (n)		T stage	Survival		P value	Recurrence		P value
Jang et al[33]	2019	South Korea	Laparoscopic	(55)	T2	5-yr OS	73.1%	0.116	5-yr DFS	78.0%	0.017a
			Open	(44)			65.7%			62.4%
Feng et al[32]	2019	China	Laparoscopic	(41)	Tis-T3	1/3/5-yr OS	97.1%/69.4%/51.9%	0.453	Postoperative incisional metastasis	4.9%	NA
			Open	(61)			94.7%/64.9%/55.7%			3.3%
			Laparoscopic	(9)	Tis	5-yr OS	100.0%	NA	NA	NA	NA
			Open	(4)			NA			NA
			Laparoscopic	(8)	T1b	5-yr OS	NA	0.763	NA	NA	NA
			Open	(9)			87.5%			NA
			Laparoscopic	(14)	T2	5-yr OS	48.1%	0.513	NA	NA	NA
			Open	(32)			64.7%			NA
			Laparoscopic	(8)	T3	5-yr OS	12.5%	0.513	NA	NA	NA
			Open	(16)			16.0%			NA
Jang et al[31]	2016	South Korea	Laparoscopic	(61)	T1	5-yr OS	92.7%	0.332	Recurrence	0.0%	0.496
			Open	(61)			100.0%			3.3%
Itano et al[30]	2015	Japan	Laparoscopic	(16)	T2	3-yr OS	100.0%	NA	3-yr recurrence	0.0%	NA
			Open	(14)			71.4%			28.6%
Agarwal et al[13]	2015	India	Laparoscopic	(24)	T1-T3	NA	NA	NA	18 mo (6–34 mo)	4.2%	NA
			Open	(46)						6.5%
Ha et al[34]	2014	South Korea	Laparoscopic	(25)	T1b/T2	1/3/5-yr OS	94.7%/64.0%/64.0%	0.607	NA	NA	NA
			Open	(150)			95%/83.4%/76.0%			NA
			Laparoscopic	(15)	T1b	1/3/5-yr OS	91.7%/68.8%/68.8%	0.649	NA	NA	NA
			Open	(75)			100.0%/87.6%/ 84.4%			NA
			Laparoscopic	(10)	T2	1/3/5-yr OS	100.0%/50.0%/50.0%	0.895	NA	NA	NA
			Open	(75)			90.0%/79.3%/67.6%			NA
Goetze et al[29]	2013	Germany	Laparoscopic	(492)	T1-T4	5-yr OS	37.0%	< 0.05a	Overall recurrence	54.9%	> 0.05
			Open	(200)			25.0%			54.5%
			Laparoscopic	(95)	T1	5-yr OS	52.0%	> 0.05	NA	NA	NA
			Open	(34)			57.0%			NA
			Laparoscopic	(282)	T2	5-yr OS	33.0%	0.002a	NA	NA	NA
			Open	(81)			25.0%			NA
			Laparoscopic	(81)	T3	5-yr OS	24.0%	0.001a	NA	NA	NA
			Open	(59)			6.0%			NA

OS: Overall survival; DFS: Disease-free survival; NA: Not available.

^aP < 0.05.