Study on the correlation and predictive value of serum pregnancy-associated plasma protein A, triglyceride and serum 25-hydroxyvitamin D levels with gestational diabetes mellitus

Table 1 Comparison of general data between the two groups

Groups	Group A (n = 51)	Group A (n = 48)	χ2/t	P value
Age (yr)	28.54 ± 6.14	28.21 ± 6.31	0.264	0.793
BMI (kg/m2)	23.24 ± 2.58	23.53 ± 2.69	0.548	0.585
Parity			10.891	0.001
Primipara	24 (47.06)	25 (52.08)	0.500	0.480
Multipara	27 (52.94)	23 (47.92)
Gestational age (wk)	9.87 ± 1.83	9.93 ± 1.87	0.161	0.872
Delivery mode (case)			0.020	0.888
Vaginal delivery	25 (49.02)	23 (47.92)
Cesarean delivery	26 (50.98)	25 (52.08)
Cholesterol (mmol/L)	5.45 ± 1.34	5.25 ± 1.42	0.721	0.473
Triglyceride (mmol/L)	1.59 ± 1.01	1.57 ± 0.98	0.100	0.921
Low density cholesterol (mmol/L)	1.38 ± 0.14	1.41 ± 0.16	0.994	0.323
High density cholesterol (mmol/L)	3.98 ± 1.37	4.23 ± 1.42	0.892	0.375
FBG during pregnancy (mmol/L)	5.64 ± 0.42	4.37 ± 0.39	15.560	< 0.001
OGTT 2 h	10.23 ± 1.43	7.34 ± 0.85	12.130	< 0.001
Glycosylated hemoglobin (%)	7.24 ± 1.35	6.02 ± 1.02	5.049	< 0.001
VEGF (pg/mL)	183.63 ± 23.24	129.23 ± 17.34	13.140	< 0.001
Flt-1 (pg/mL)	2453.62 ± 823.24	1536.69 ± 782.74	5.672	< 0.001

VEGF: Vascular endothelial growth factor; BMI: Body mass index; FBG: Fasting blood glucose; OGTT: Oral glucose tolerance test.

Table 2 Comparison of serum pregnancy-associated plasma protein A, triglyceride, and 25-hydroxyvitamin D levels between the two groups

Groups	Group A (n = 51)	Group A (n = 48)	t	P value
PAPP-A (ng/L)	13.84 ± 2.03	16.96 ± 2.45	4.699	< 0.001
TG (mmol/L)	2.12 ± 0.61	1.32 ± 0.56	6.785	< 0.001
25-(OH)D (ng/mL)	20.34 ± 5.13	24.52 ± 5.42	3.942	< 0.001

PAPP-A: Pregnancy-associated plasma protein A; TG: Triglyceride; 25-(OH)D: 25-hydroxyvitamin D.

Table 3 Assignment table

Factors	Assignments
VEGF	Raw data analysis for continuous variables
Flt-1	Raw data analysis for continuous variables
FBG during pregnancy	Raw data analysis for continuous variables
Serum PAPP-A	Raw data analysis for continuous variables
25-(OH)D	Raw data analysis for continuous variables
TG	Raw data analysis for continuous variables

VEGF: Vascular endothelial growth factor; FBG: Fasting blood glucose; PAPP-A: Pregnancy-associated plasma protein A; TG: Triglyceride; 25-(OH)D: 25-hydroxyvitamin D.

Table 4 Logistic regression analysis of influencing factors in gestational diabetes mellitus

Factors	B	SE	Wals	Sig.	Exp (B)	95%CI for Exp (B)
						Lower	Upper
VEGF	0.563	0.281	2.762	0.044	1.723	0.874	3.013
Flt-1	-0.023	0.142	2.642	0.041	0.974	0.722	1.332
FBG during pregnancy	0.572	0.279	4.028	0.042	1.782	1.036	3.052
Serum PAPP-A	0.937	0.328	5.028	0.026	2.530	1.348	4.791
25-(OH)D	0.228	0.078	4.028	0.046	1.259	1.079	1.457
TG	-0.362	0.169	3.978	0.044	0.695	0.508	0.964

B: Constant term; SE: Standard deviation; Wals: χ² value; sig: P value, Exp (B): Odds ratio; 95%CI for Exp (B): Odds ratio: 95% confidence interval; VEGF: Vascular endothelial growth factor; FBG: Fasting blood glucose; PAPP-A: Pregnancy-associated plasma protein A; TG: Triglyceride; 25-(OH)D: 25-hydroxyvitamin D.