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©The Author(s) 2020.
World J Clin Cases. Dec 6, 2020; 8(23): 5935-5943
Published online Dec 6, 2020. doi: 10.12998/wjcc.v8.i23.5935
Published online Dec 6, 2020. doi: 10.12998/wjcc.v8.i23.5935
Table 1 Relationship between CD155 expression and pathological characteristics
CD155 expression | P value | ||
Negative (n = 78) | Positive (n = 48) | ||
Age1, mean ± SD (yr) | 58.2 ± 13.87 | 57.8 ± 13.26 | 0.914 |
Histological grade2, n (%) | 0.112 | ||
I | 11 (15.3) | 2 (4.3) | |
II | 47 (65.3) | 32 (69.6) | |
III | 14 (19.4) | 12 (26.1) | |
TNM stage2, n (%) | 0.662 | ||
I | 20 (27.0) | 10 (21.3) | |
II | 39 (52.7) | 28 (59.6) | |
III | 12 (16.2) | 6 (12.8) | |
IV | 3 (4.1) | 3 (6.4) | |
Molecular subtype3, n (%) | 0.002 | ||
Luminal A | 49 (77.8) | 14 (22.2) | |
Luminal B | 16 (51.6) | 15 (48.4) | |
HER2 over-expression | 5 (50.0) | 5 (50.0) | |
Triple negative | 3 (27.3) | 8 (72.7) |
Table 2 Association between CD155 expression and percentage of tumor infiltrating lymphocytes phenotypes1
CD155 expression | P value | ||
TILs phenotypes | Negative (n = 78) | Positive (n = 48) | |
CD4+ TILs, mean ± SD | 60% ± 22% | 61% ± 22% | 0.788 |
CD4+/PD-1+ TILs, mean ± SD | 21% ± 20% | 30% ± 19% | 0.004 |
CD4+/PD-1- TILs, mean ± SD | 39% ± 20% | 31% ± 19% | 0.032 |
CD8+ TILs, mean ± SD | 23% ± 13% | 24% ± 11% | 0.342 |
CD8+/PD-1+ TILs, mean ± SD | 4% ± 5% | 5% ± 5% | 0.280 |
CD8+/PD-1- TILs, mean ± SD | 19% ± 10% | 20% ± 9% | 0.437 |
Table 3 Association between CD155 expression and cell counts of tumor infiltrating lymphocytes phenotypes1
TILs phenotypes | CD155 expression | P value | |
Negative (n = 78) | Positive (n = 48) | ||
CD4+ TILs, mean ± SD | 54 ± 46 | 87 ± 93 | 0.041 |
CD4+/PD-1+ TILs, mean ± SD | 20 ± 24 | 47 ± 57 | 0.002 |
CD4+/PD-1- TILs, mean ± SD | 34 ± 30 | 41 ± 45 | 0.658 |
CD8+ TILs, mean ± SD | 21 ± 20 | 37 ± 44 | 0.040 |
CD8+/PD-1+ TILs, mean ± SD | 4 ± 5 | 7 ± 13 | 0.069 |
CD8+/PD-1- TILs, mean ± SD | 17 ± 17 | 30 ± 35 | 0.040 |
- Citation: Wang RB, Li YC, Zhou Q, Lv SZ, Yuan KY, Wu JP, Zhao YJ, Song QK, Zhu B. Overexpression of CD155 is associated with PD-1 and PD-L1 expression on immune cells, rather than tumor cells in the breast cancer microenvironment. World J Clin Cases 2020; 8(23): 5935-5943
- URL: https://www.wjgnet.com/2307-8960/full/v8/i23/5935.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v8.i23.5935