Hepatic epithelioid hemangioendothelioma: Update on diagnosis and therapy

Table 1 Clearly shows the differential diagnosis between hepatic epithelioid hemangioendothelioma and other diseases

	Typical imaging features	Immunohistochemical staining markers	Molecular biology
HEHE	Target sign, lollipop sign, capsular retraction	CD31, CD34, CD10, vimentin, Factor VIII antigen	Fusion gene: WWTR1-CAMTA1, YAP1-TFE3
Angiosarcoma	Heterogeneous centripetal enhancement	CD31, CD34, Factor VIII antigen	HRAS, KRAS, NRAS and PTPRB mutation
HH	Posterior shadowing and centripetal filling	-	-
Cholangio carcinoma	Cholangiectasis, capsular retraction	Pan-cytokeratin	-
Hepatocellular carcinoma	Hyperechoic enhancement in the arterial phase and hypoechoic enhancement in the portal and delayed phases	HepPar-1; Pan-cytokeratin	-
Metastatic carcinoma	Bull's-eye sign	Pan-cytokeratin	-

HEHE: Hepatic epithelioid hemangioendothelioma; HH: Hepatic hemangioma.