Natural killer/T-cell lymphoma with intracranial infiltration and Epstein-Barr virus infection: A case report

doi:10.12998/wjcc.v8.i15.3284

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Report

World J Clin Cases. Aug 6, 2020; 8(15): 3284-3290
Published online Aug 6, 2020. doi: 10.12998/wjcc.v8.i15.3284

Table 1 Examination and treatment of the patient

	Before treatment	1	2	3	4	5	6	7
Pathology		Frozen pathology: RMS	NKTL
Regimens	Ganciclovir and antibiotic	AVCP	SMILE	SMILE	VIPD	SMILE	SMILE	VIPD
Intrathecal injection			Yes	Yes	Yes	Yes	Yes	Yes
CSF tests			Normal	Normal	Normal	Normal	Normal	Normal
CSF Flow cytometry			Negative					Negative
CSF-NSE (ng/mL)			21.7	25.5	21.4	19.7	17.1	16.2
Blood-NSE (ng/mL)	68.3		31.9					27.6
LDH (U/L)	733	372	354	202	277	221	205	263
ALT (U/L)	207	113	33.3	103	72	22.6	76.2	46
Blood EB-DNA (copies/mL)	8.798 × 10⁴	7.699 × 10⁴		5.765 × 10²		1.115 × 10³	Negative
Imaging examination	Eyelid CT and Head CT	Eyelid MRI			PET-CT			Brain enhanced MR-Figure4
Chest X-ray/CT	Normal				PET-CT			Normal
Abdominal ultrasound	Normal		Normal		PET-CT			Normal
Lymph node ultrasound	Reactive hyperplasia-neck				PET-CT			Reactive hyperplasia-neck
Bone marrow	Negative				Negative			Negative
Chemotherapy complications		Low fibrinogenemia, oral mucositis, diarrhea, bronchial pneumonia, neutropenia with fever, liver function damage, myocardial damage, and severe myelosuppression

RMS: Rhabdomyosarcoma; NKTL: Natural killer/T-cell lymphoma; CSF: Cerebrospinal fluid; NSE: Neuron-specific enolase; LDH: Lactate dehydrogenase; ALT: Alanine aminotransferase; EB: Epstein-Barr virus; CT: Computed tomography; MRI: Magnetic resonance; PET-CT: Positron emission tomography-computed tomography.

Citation: Li N, Wang YZ, Zhang Y, Zhang WL, Zhou Y, Huang DS. Natural killer/T-cell lymphoma with intracranial infiltration and Epstein-Barr virus infection: A case report. World J Clin Cases 2020; 8(15): 3284-3290
URL: https://www.wjgnet.com/2307-8960/full/v8/i15/3284.htm
DOI: https://dx.doi.org/10.12998/wjcc.v8.i15.3284