Altered physiology of mesenchymal stem cells in the pathogenesis of adolescent idiopathic scoliosis

doi:10.12998/wjcc.v8.i11.2102

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Jun 6, 2020; 8(11): 2102-2110
Published online Jun 6, 2020. doi: 10.12998/wjcc.v8.i11.2102

Table 1 Summary table showing differentially expressed genes, proteins, and non-coding RNAs of adolescent idiopathic scoliosis patient-derived mesenchymal stem cells compared to normal controls

Function	Gene	Protein	ncRNA
Decreased osteogenic differentiation	1027 DEGs	25 distinct proteins	1483 differentially expressed lncRNAs 54 differentially expressed miRNAs
Decreased osteogenic differentiation	24 central genes (MAP2K1, SMAD3, HOXC6, HSPA7, GTF2I, etc.)	β-actin, γ-actin, HSP27, etc.↓ PKM2↑	lncAIS 204 target genes (MAP2K1, SMAD3, GTF21, etc.)
Desensitization against melatonin	SPRY4↓	MT2↓

ncRNA: Non-coding RNA; DEG: Differentially expressed gene; lncRNA: Long non-coding RNA; miRNA: microRNA; PKM2: Pyruvate kinase M2; MT2: Melatonin receptor 2.

Citation: Ko DS, Kim YH, Goh TS, Lee JS. Altered physiology of mesenchymal stem cells in the pathogenesis of adolescent idiopathic scoliosis. World J Clin Cases 2020; 8(11): 2102-2110
URL: https://www.wjgnet.com/2307-8960/full/v8/i11/2102.htm
DOI: https://dx.doi.org/10.12998/wjcc.v8.i11.2102