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©The Author(s) 2019.
World J Clin Cases. Apr 26, 2019; 7(8): 940-950
Published online Apr 26, 2019. doi: 10.12998/wjcc.v7.i8.940
Published online Apr 26, 2019. doi: 10.12998/wjcc.v7.i8.940
Table 1 Clinical, electrocardiography and echocardiographic characteristics based on their E/A ratio
All subjects (n = 414) | E/A ≥ 0.75 (n = 300) | E/A < 0.75 (n = 114) | P-value | |
Age (yr) | 55.21 ± 14.18 | 55.25 ± 13.20 | 69.62 ± 11.05 | < 0.001 |
Male n (%) | 186 (44.9%) | 124 (41.3%) | 62 (55.4%) | 0.017 |
BMI (kg/m2) | 23.68 ± 3.00 | 23.41 ± 2.93 | 24.37 ± 3.08 | 0.004 |
SBP (mmHg) | 125.64 ± 12.69 | 123.05 ± 12.68 | 132.43 ± 9.93 | < 0.001 |
DBP (mmHg) | 75.97 ± 8.84 | 74.92 ± 8.97 | 78.73 ± 7.87 | < 0.001 |
TG (mmol/L) | 1.38 ± 1.10 | 1.39 ± 1.18 | 1.36 ± 0.84 | 0.840 |
TC (mmol/L) | 5.23 ± 1.05 | 5.22 ± 1.08 | 5.26 ± 0.98 | 0.722 |
HDL-C (mmol/L) | 1.64 ± 0.41 | 1.65 ± 0.40 | 1.62 ± 0.44 | 0.440 |
LDL-C (mmol/L) | 2.90 ± 0.75 | 2.88 ± 0.76 | 2.95 ± 0.70 | 0.448 |
FBG (mmol/L) | 5.55 ± 0.49 | 5.54 ± 0.48 | 5.60 ± 0.53 | 0.248 |
SCr (μmol/L) | 64.37 ± 14.46 | 62.72 ± 13.23 | 68.71 ± 16.58 | < 0.001 |
PR interval (ms) | 157.08 ± 23.73 | 156.36 ± 24.18 | 158.97 ± 22.50 | 0.302 |
RR interval (ms) | 905.53 ± 126.29 | 915.40 ± 118.32 | 879.56 ± 142.52 | 0.010 |
QT interval (ms) | 372.81 ± 30.07 | 371.45 ± 29.49 | 376.39 ± 31.40 | 0.136 |
QTc interval (ms) | 393.52 ± 29.44 | 393.59 ± 26.74 | 403.86 ± 33.56 | < 0.001 |
Tpe interval (ms) | 73.94 ± 14.25 | 72.68 ± 12.41 | 77.26 ± 17.86 | 0.003 |
Tpec interval (ms) | 78.27 ± 16.30 | 76.36 ± 13.53 | 83.32 ± 21.25 | < 0.001 |
Tpe/QT | 0.20 ± 0.03 | 0.19 ± 0.03 | 0.20 ± 0.04 | 0.004 |
Tpe/QTc | 0.19 ± 0.03 | 0.19 ± 0.03 | 0.19 ± 0.03 | 0.160 |
E (cm/s) | 74.36 ± 17.83 | 80.27 ± 16.20 | 58.82 ± 11.49 | < 0.001 |
A (cm/s) | 75.07 ± 19.21 | 68.75 ± 16.70 | 91.69 ± 15.07 | < 0.001 |
E/A | 1.07 ± 0.41 | 1.23 ± 0.36 | 0.64 ± 0.08 | < 0.001 |
MV-DT (ms) | 162.78 ± 35.15 | 159.43 ± 31.14 | 171.60 ± 42.92 | 0.002 |
LAV (mL) | 33.16 ± 9.73 | 32.30 ± 9.70 | 35.42 ± 9.48 | 0.003 |
LAVI (mL/m2) | 19.83 ± 5.31 | 19.38 ± 5.29 | 21.01 ± 5.22 | 0.005 |
LVEF (%) | 62.54 ± 4.71 | 62.86 ± 4.47 | 61.68 ± 5.21 | 0.023 |
Table 2 Correlation analysis between electrocardiography repolarization variables and other variables
QT (ms) | QTc (ms) | Tpe (ms) | Tpec (ms) | Tpe/QT | Tpe/QTc | |
Age (yr) | 0.223b | 0.281b | 0.167b | 0.169b | 0.109a | 0.090 |
BMI (kg/m2) | 0.073 | 0.109a | 0.119a | 0.124a | 0.120a | 0.100a |
SBP (mmHg) | 0.082 | 0.167b | 0.059 | 0.089 | 0.049 | 0.004 |
DBP (mmHg) | -0.031 | 0.029 | -0.034 | -0.008 | -0.005 | -0.036 |
TG (mmol/L) | -0.02 | 0.028 | 0.058 | 0.073 | 0.086 | 0.058 |
TC (mmol/L) | 0.009 | 0.115a | 0.054 | 0.094 | 0.071 | 0.020 |
HDL-C (mmol/L) | -0.061 | -0.067 | -0.132b | -0.122a | -0.140b | -0.130b |
LDL-C (mmol/L) | -0.046 | 0.155b | 0.088 | 0.127a | 0.098a | 0.042 |
FBG ( mmol/L ) | -0/089 | 0.080 | 0.015 | 0.074 | 0.081 | 0.001 |
SCr (μmol/L) | -0/013 | -0.055 | 0.089 | 0.068 | 0.123a | 0.146b |
E (cm/s) | 0.051 | -0.093 | -0.072 | -0.121a | -0.138b | -0.060 |
A (cm/s) | 0.152b | 0.324b | 0.189b | 0.237b | 0.157b | 0.079 |
E/A | -0.070 | -0.288b | -0.155b | -0.223b | -0.175b | -0.067 |
DT (ms) | 0.244b | -0.028 | 0.073 | -0.047 | -0.039 | 0.102a |
LAV (mL) | 0.312b | 0.209b | 0.157b | 0.099a | 0.038 | 0.100a |
LAVI (mL/m2) | 0.354 | 0.255b | 0.148b | 0.091 | 0.002 | 0.062 |
Table 3 Relationship between electrocardiography repolarization variables and echocardiographic diastolic parameters using a stepwise multiple regression model
Model 1 | Model 2 | Model 3 | ||||
Beta | P-value | Beta | P-value | Beta | P-value | |
QT interval (ms) | ||||||
A (cm/s) | 0.152 | 0.002 | 0.033 | 0.435 | 0.028 | 0.504 |
DT (ms) | 0.244 | < 0.001 | 0.194 | < 0.001 | 0.182 | < 0.001 |
LAV (mL) | 0.312 | < 0.001 | 0.271 | < 0.001 | 0.248 | < 0.001 |
QTc interval (ms) | ||||||
A (cm/s) | 0.324 | < 0.001 | 0.186 | < 0.001 | 0.178 | < 0.001 |
E/A | -0.288 | < 0.001 | -0.131 | 0.001 | -0.105 | 0.008 |
LAV (mL) | 0.209 | < 0.001 | 0.152 | 0.002 | 0.105 | 0.019 |
LAVI (mL/m2) | 0.255 | < 0.001 | 0.181 | < 0.001 | 0.142 | 0.003 |
Tpe (ms) | ||||||
A (cm/s) | 0.189 | < 0.001 | 0.102 | 0.015 | 0.099 | 0.016 |
E/A | -0.155 | 0.002 | -0.057 | 0.153 | -0.035 | 0.355 |
LAV (mL) | 0.157 | 0.001 | 0.119 | 0.014 | 0.167 | 0.120 |
LAVI (mL/m2) | 0.148 | 0.003 | 0.098 | 0.039 | 0.080 | 0.086 |
Tpec (ms) | ||||||
E (cm/s) | -0.121 | 0.014 | -0.062 | 0.185 | -0.032 | 0.489 |
A (cm/s) | 0.237 | < 0.001 | 0.150 | < 0.001 | 0.143 | < 0.001 |
E/A | -2.223 | < 0.001 | -0.126 | 0.002 | -0.098 | 0.010 |
LAV (mL) | 0.099 | 0.045 | 0.059 | 0.233 | 0.015 | 0.749 |
Tpe/QT | ||||||
E (cm/s) | -0.138 | 0.005 | -0.100 | 0.030 | -0.066 | 0.152 |
A (cm/s) | 0.157 | 0.001 | 0.099 | 0.017 | 0.097 | 0.018 |
E/A | -0.175 | < 0.001 | -0.111 | 0.005 | -0.083 | 0.028 |
Tpe/QTc | ||||||
DT (ms) | 0.102 | 0.038 | 0.078 | 0.101 | 0.072 | 0.139 |
LAV (mL) | 0.100 | 0.041 | 0.079 | 0.100 | 0.037 | 0.388 |
Table 4 Association of E/A ratio within tertiles of QTc and Tpec using binary logistic regression model
Tertile 1 | Tertile 2 | Tertile 3 | |||||||
Model 1 | Model 2 | Model 1 | Model 2 | ||||||
OR (95%CI) | P-value | OR (95%CI) | P-value | OR (95%CI) | P-value | OR (95%CI) | P-value | OR | |
Tertiles of QTc | |||||||||
Men (n = 186) | 0.604 (0.272-1.342) | 0.216 | 0.763 (0.317-1.836) | 0.545 | 0.210 (0.087-0.506) | 0.001 | 0.257 (0.102-0.649) | 0.004 | 1 (ref) |
Women (n = 228) | 0.527 (0.176-1.579) | 0.253 | 0.982 (0.284-3.396) | 0.977 | 1.230 (0.539-2.806) | 0.624 | 1.480 (0.574-3.815) | 0.417 | 1 (ref) |
Tertiles of Tpec | |||||||||
Men (n = 186) | 0.890 (0.397-1.996) | 0.777 | 0.980 (0.404-2.372) | 0.963 | 0.465 (0.204-1.061) | 0.069 | 0.423 (0.175-1.022) | 0.056 | 1 (ref) |
Women (n = 228) | 0.483 (0.188-1.242) | 0.131 | 0.477 (0.162-1.404) | 0.179 | 0.487 (0.204-1.160) | 0.104 | 0.532 (0.200-1.416) | 0.206 | 1 (ref) |
- Citation: Li ZD, Bai XJ, Han LL, Han W, Sun XF, Chen XM. Association between ventricular repolarization variables and cardiac diastolic function: A cross-sectional study of a healthy Chinese population. World J Clin Cases 2019; 7(8): 940-950
- URL: https://www.wjgnet.com/2307-8960/full/v7/i8/940.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v7.i8.940