Correlation analysis of collagen proportionate area in Budd-Chiari syndrome: A preliminary clinicopathological study

Table 1 Patient characteristics

Variable	n	Frequency [n (%), or mean ± SD]	Median (range)
Age	9	30.00 ± 15.75	29.00 (12.00-60.00)
Gender (male/female)	9	4 (44.4)/5 (55.6)
Hepatitis B virus	9	0 (0)
Hepatitis C virus	9	0 (0)
Alcohol abuse	9	0 (0)
Vascular obstruction
IVC obstruction	9	2 (22.2)
RHV obstruction	9	8 (88.9)
MHV obstruction	9	7 (77.8)
LHV obstruction	9	9 (100.0)
All HVs obstruction	9	6 (66.7)
Portal vein thrombosis	9	0 (0)
Clinical presentations and signs
Hepatic encephalopathy before TIPS	9	0 (0)
Gastrointestinal bleeding	9	3 (33.3)
Abdominal pain	9	2 (22.2)
Abdominal distension	9	7 (77.8)
Abdominal varices	9	1 (11.1)
Limb swelling	9	1 (11.1)
Pigmentation	9	1 (11.1)
Limb ulcer	9	1 (11.1)
CT signs
Hydrothorax on CT	9	3 (33.3)
Ascites on CT	9	4 (44.4)
Splenomegaly on CT	9	8 (88.9)
Hepatic patchy enhancement on CT	9	7 (77.8)
Gastroesophageal varices on CT	9	7 (77.8)
Paraesophageal varices on CT	9	1 (11.1)
Laboratory tests
Hemoglobin (g/L)	9	122.67 ± 34.81	127.00 (82.00-171.00)
White blood cell (109/L)	9	6.86 ± 2.85	6.67 (2.99-12.48)
Platelet count (109/L)	9	122.22 ± 69.32	109.00 (42.00-270.00)
Alanine aminotransferase (U/L)	9	29.22 ± 17.56	23.00 (13.00-71.00)
Aspartate aminotransferase (U/L)	9	47.22 ± 20.97	39.00 (18.00-71.00)
Alkaline phosphatase (U/L)	9	178.33 ± 69.20	148.00 (96.00-288.00)
Gamma glutamyl transferase (U/L)	9	93.44 ± 42.21	84.00 (19.00-161.00)
Total bilirubin (mmol/L)	9	86.98 ± 91.81	42.80 (18.90-262.40)
Direct bilirubin (mmol/L)	9	57.71 ± 68.42	17.30 (6.20-180.00)
Albumin (g/L)	9	36.19 ± 7.08	39.60 (22.20-44.10)
Prothrombin time (s)	9	55.67 ± 15.33	56.00 (25.00-78.00)
International normalized ratio	9	1.48 ± 0.43	1.37 (1.12-2.55)
Serum creatinine (mmol/L)	9	51.00 ± 14.65	50.00 (29.00-76.00)
Blood urea nitrogen (mmol/L)	9	5.06 ± 1.51	5.15 (2.94-8.27)
Sodium (mmol/L)	9	134.78 ± 8.56	138.00 (120.00-143.00)
Potassium (mmol/L)	9	4.33 ± 0.64	4.17 (3.77-5.77)
Collagen proportionate area	9	23.44 ± 13.88	23.07 (0-40.20)
Shunt dysfunction after TIPS	9	2 (22.2)
Hepatic encephalopathy after TIPS	9	1 (11.1)

CT: Computer tomography; HV: Hepatic vein; IVC: Inferior vena cava; LHV: Left hepatic vein; MHV: Middle hepatic vein; RHV: Right hepatic vein; TIPS: Transjugular intrahepatic portosystemic shunt.

Table 2 Correlation analysis of collagen proportionate area

Variable	n	Pearson coefficient	P value
Age	9	0.360	0.342
Gender (male/female)	9	0.038	0.922
Hepatitis B virus	9	NA	NA
Hepatitis C virus	9	NA	NA
Alcohol abuse	9	NA	NA
Vascular obstruction
IVC obstruction	9	-0.390	0.300
RHV obstruction	9	-0.502	0.168
MHV obstruction	9	-0.136	0.726
LHV obstruction	9	NA	NA
All HVs obstruction	9	-0.455	0.218
Portal vein thrombosis	9	NA	NA
Clinical presentations and signs
Hepatic encephalopathy before TIPS	9	NA	NA
Gastrointestinal bleeding	9	0.832	0.005
Abdominal pain	9	-0.257	0.504
Abdominal distension	9	-0.093	0.813
Abdominal varices	9	-0.342	0.367
Limb swelling	9	-0.233	0.547
Pigmentation	9	-0.342	0.367
Limb ulcer	9	NA	NA
CT signs
Hydrothorax on CT	9	0.142	0.716
Ascites on CT	9	-0.012	0.975
Splenomegaly on CT	9	-0.502	0.168
Hepatic patchy enhancement on CT	9	-0.037	0.924
Gastroesophageal varices on CT	9	0.219	0.572
Paraesophageal varices on CT	9	0.633	0.067
Laboratory tests
Hemoglobin (g/L)	9	0.157	0.687
White blood cell (109/L)	9	-.025	0.949
Platelet count (109/L)	9	0.242	0.530
Alanine aminotransferase (U/L)	9	-0.694	0.038
Aspartate aminotransferase (U/L)	9	-0.642	0.062
Alkaline phosphatase (U/L)	9	-0.358	0.344
Gamma glutamyl transferase (U/L)	9	0.080	0.837
Total bilirubin (μmol/L)	9	-0.338	0.373
Direct bilirubin (μmol/L)	9	-0.415	0.267
Albumin (g/L)	9	0.348	0.358
Prothrombin time (seconds)	9	0.68	0.044
International normalized ratio	9	-0.638	0.065
Serum creatinine (μmol/L)	9	0.019	0.962
Blood urea nitrogen (mmol/L)	9	-0.411	0.272
Sodium (mmol/L)	9	0.272	0.478
Potassium (mmol/L)	9	-0.376	0.319
Shunt dysfunction after TIPS	9	-0.168	0.665
Hepatic encephalopathy after TIPS	9	-0.453	0.221

CT: Computed tomography; HV: Hepatic vein; IVC: Inferior vena cava; LHV: Left hepatic vein; MHV: Middle hepatic vein; RHV: Right hepatic vein; TIPS: Transjugular intrahepatic portosystemic shunt; NA: Not available.