Case Control Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 26, 2019; 7(2): 130-136
Published online Jan 26, 2019. doi: 10.12998/wjcc.v7.i2.130
Correlation analysis of collagen proportionate area in Budd-Chiari syndrome: A preliminary clinicopathological study
Fu-Liang He, Chuan Li, Fu-Quan Liu, Xing-Shun Qi
Fu-Liang He, Fu-Quan Liu, Department of Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
Chuan Li, Xing-Shun Qi, Liver Cirrhosis Study Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang 110016, Liaoning Province, China
Chuan Li, Section of Medical Services, General Hospital of Shenyang Military Area, Shenyang 110016, Liaoning Province, China
Author contributions: He FL, Li C, and Liu FQ contributed equally as co-first authors; Liu FQ and Qi XS designed the study; He FL, Li C, and Qi XS wrote the manuscript.
Supported by the National Natural Science Foundation of China, No. 81500474; and Training Programme Foundation for Beijing Talents, No. 2016000021469G206.
Institutional review board statement: The study was approved by the ethics committee of Beijing Shijitan Hospital of the Capital Medical University.
Informed consent statement: All patients gave informed consent.
Conflict-of-interest statement: No conflict of interest.
STROBE statement: The STROBE checklist has been confirmed.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Xing-Shun Qi, MD, Vice-Chief Physician, Liver Cirrhosis Study Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, No. 83 Wenhua Road, Shenyang 110016, Liaoning Province, China. xingshunqi@126.com
Telephone: +86-24-28897606 Fax: +86-24-28851113
Received: October 19, 2018
Peer-review started: October 19, 2018
First decision: November 15, 2018
Revised: December 1, 2018
Accepted: December 12, 2018
Article in press: December 12, 2018
Published online: January 26, 2019
Processing time: 100 Days and 4.8 Hours
Abstract
BACKGROUND

Collagen proportionate area (CPA) is an important index for assessing the severity of liver fibrosis. Budd-Chiari syndrome can frequently progress to liver fibrosis and cirrhosis. CPA might play an important role in the pathological progress of Budd-Chiari syndrome.

AIM

To explore the role of CPA in predicting the outcomes of patients with Budd-Chiari syndrome.

METHODS

Nine patients with Budd-Chiari syndrome undergoing transjugular intrahepatic portosystemic shunt (TIPS) were included. The median CPA level and correlation of CPA and prognosis of TIPS were determined.

RESULTS

Median CPA was 23.07% (range: 0%-40.20%). Pearson’s χ2 test demonstrated a significant correlation of CPA with history of gastrointestinal bleeding (Pearson’s coefficient: 0.832, P = 0.005), alanine aminotransferase (Pearson’s coefficient: -0.694, P = 0.038), and prothrombin time (Pearson’s coefficient: 0.68, P = 0.044). Although CPA was not significantly correlated with shunt dysfunction or hepatic encephalopathy after TIPS, the absolute CPA was relatively larger in patients who developed shunt dysfunction or hepatic encephalopathy after TIPS.

CONCLUSION

This preliminary clinicopathological study found a marginal effect of CPA on the outcomes of Budd-Chiari syndrome patients treated with TIPS.

Keywords: Budd-Chiari syndrome; Hepatic vein; Occlusion; Thrombosis; Fibrosis

Core tip: In the nine patients recruited for the study, we found a marginal effect of collagen proportionate area on the outcomes of Budd-Chiari syndrome patients treated with transjugular intrahepatic portosystemic shunt.