Small cell lung cancer starting with diabetes mellitus: Two case reports and literature review

Table 1 Laboratory examination results in Case 1 (only abnormal results shown)

Items		Test result	Normal range
HbA1c		8.2%	< 6.5%
γ-GT		65.0 U/L	5.0–54.0 U/L
Serum ions	K+	2.2 mmol/L	3.5–5.5 mmol/L
	Na+	135.0 mmol/L	137–145 mmol/L
	Cl+	94.9 mmol/L	98–107 mmol/L
	Ca2+	1.8 mmol/L	2.1–2.55 mmol/L
Urine glucose		3 +	Negative
Thyroid function	TSH	0.6 μIU/mL	0.27–4.2 μIU/mL
	FT3	2.4 pmol/L	3.1–6.8 pmol/L
	FT4	10.2 pmol/L	12.0–22.0 pmol/L
ACTH, 8 hr		36.9 pmol/L	1.6–13.9 pmol/L
Cortisol, 8 hr		1027.6 nmol/L	240–619 nmol/L
24-hr UFC		12221.0 nmol	108–961 nmol/L
Urine	K+	74.0 mmol/24 hr	51–102 mmol/24 hr
	Na+	339.5 mmol/24 hr	130–260 mmol/24 hr
	Ca2+	7.5 mmol/24 hr	2.5–7.5 mmol/24 hr
	Cl−	300.0 mmol/24 hr	100–250 mmol/24 hr
Dexamethasone-suppression test, at overnight, low-dose and high-dose		No suppression	Suppressed

HbA1c: Hemoglobin A1c; γ-GT: Gamma glutamyltransferase; ACTH: Adrenocorticotropic hormone; TSH: Thyroid-stimulating hormone; FT3: Free tri-iodothyronine; FT4: Free thyroxine; UFC: Urinary free cortisol.

Table 2 Laboratory examination results in Case 2 (only abnormal results shown)

Items		Test result	Normal range
HbA1c		9.4%	< 6.5%
Fasting glucose		11.2 mmol/L	3.9–6.1 mmol/L
blood routine	NE %	0.8	0.5–0.7
	RBC	3.97×1012/L	4.0×1012–5.5×1012/L
	HGB	111.0 g/L	120–160 g/L
Urine glucose		1 +	Negative
Thyroid function	TSH	0.04 μIU/mL	0.27–4.2 μIU/mL
	FT3	2.8 pmol/L	3.1–6.8 pmol/L
	FT4	11.7 pmol/L	12.0–22.0 pmol/L
Ion, serum	K+	2.5–3.3 mmol/L	3.5–5.5 mmol/L
	Ca2+	1.7–1.9 mmol/L	2.1–2.55 mmol/L
ACTH, 8 hr		167.1 pmol/L	1.6–13.9 pmol/L
Cortisol, 8 hr		> 1710.5 nmol/L	240–619 nmol/L
24-h UFC		12762.3 nmol/L	108–961 nmol/L
CEA		5.6 ng/mL	< 5 ng/mL

HbA1c: Hemoglobin A1c; NE: Neutrophil; RBC: Red blood cell; HGB: Hemoglobin; TSH: Thyroid-stimulating hormone; FT3: Free tri-iodothyronine; FT4: Free thyroxine; ACTH: Adrenocorticotropic hormone; UFC: Urinary free cortisol; CEA: Carcinoembryonic antigen.