Benefits of the Seattle biopsy protocol in the diagnosis of Barrett’s esophagus in a Chinese population

Table 1 General data and endoscopic appearances of groups A and B

	Group A (n = 20)		Group B (n = 78)		P-value
	mean ± SD	n (%)	mean ± SD	n (%)
Age (yr)	60.95 ± 17.29		55.19 ± 13.28		0.1891
Gender (male)		9 (45.0)		35 (44.9)	0.9922
BMI (kg/m2)	25.76 ± 4.52		23.69 ± 3.59		0.0791
EE		7 (35.0)		15 (19.2)	0.1322
Hiatus hernia		8 (40.0)		15 (19.2)	0.0512
LSBE		2 (10.0)		3 (3.8)	0.2692
Biopsy pieces	4.58 ± 1.57		3.39 ± 1.74		0.0091

¹P-values were analyzed with t-test;

²P-values were analyzed with Pearson’s χ² test. BMI: Body mass index; EE: Erosive esophagitis; LSBE: Long segment Barrett’s esophagus.

Table 2 General data and endoscopic appearances of groups C and D

	Group C (n = 31)		Group D (n = 14)		P-value
	mean ± SD	n (%)	mean ± SD	n (%)
Age (yr)	66.53 ± 12.47		65.79 ± 14.18		0.8601
Gender (male)		25 (80.6)		12 (85.7)	0.5182
BMI (kg/m2)	25.65 ± 3.70		23.14 ± 3.64		0.0511
EE		6 (19.4)		8 (57.1)	0.0112
Hiatus hernia		17 (54.8)		6 (42.9)	0.4572
LSBE		9 (29.0)		2 (14.3)	0.2872
Biopsy pieces	5.69 ± 2.82		4.00 ± 2.18		0.0391

¹P-values were analyzed with t-test;

²P-values were analyzed with Pearson’s χ² test. BMI: Body mass index; EE: Erosive esophagitis; LSBE: Long segment Barrett’s esophagus.

Table 3 Results of the two different biopsy protocols n (%)

	NBI-targeted biopsy	Seattle protocol-guided biopsy	P-value
IM (n = 65)	45 (69.2)	51 (78.5)	0.2312
Dysplastic tissue
Group A (n = 20)	0 (0.0)	2 (10.0)2	0.4871
Group B (n = 31)	1 (3.2)2	3 (9.6)1	0.6121
Group C (n = 14)	0 (0.0)	0 (0.0)	1.0001

¹P-values were analyzed with Fisher’s exact test;

²P-values were analyzed with Pearson’s χ² test. All dysplastic tissues were low-grade dysplasia except one adenocarcinoma in Group B detected via Seattle protocol guided biopsy. IM: Intestinal metaplasia; NBI: Narrow-band imaging.