Adjuvant chemotherapy and acute toxicity in hypofractionated radiotherapy for early breast cancer

Table 1 Patients’ characteristics

Age median (range)	58.5 (35-86)
T1	81
T2	35
Chemotherapy
Yes	83
No	33

Table 2 Incidence of acute skin toxicity in terms of previous chemotherapy or not

		EORTC/RTOG radiation induced acute skin toxicity grade				Total
		0	1	2	3
Chemotherapy	No	56/83 (67.5%)	18/83 (21.7%)	7/83 (8.4%)	2/83 (2.4%)	83
	Yes	16/33 (48.5%)	14/33 (42.4%)	2/33 (6.0%)	1/33 (3.0%)	33
Total		72/116 (62.1%)	32/116 (27.6%)	9/116 (7.8%)	3/116 (2.6%)	116

No significant correlation was noted (Pearson χ²P = 0.15). EORTC/RTOG: Organization for Research and Treatment of Cancer/Radiation Therapy.

Table 3 Logistic regression analysis performed for analyzing the contribution of age, chemotherapy and radiotherapy fractions (19 vs 20) to the development of acute radiation induced skin toxicity

	Univariate analysis			Multivariate analysis
	P	RR	95%CI	P	RR	95%CI
Age	0.31	-	-	0.41	-	-
Chemotherapy	0.05	2.35	1.01-5.52	0.057	-	-
19 vs 20 fractions	0.55	-	-	0.66	-	-

The univariate model chi-square with 3 degrees of freedom was 4.97 (P = 0.17). None of the variables entered to the multivariate model. RR: Risk ratio.