Adjuvant chemotherapy and acute toxicity in hypofractionated radiotherapy for early breast cancer

doi:10.12998/wjcc.v2.i11.705

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World Journal of Clinical Cases

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Nov 16, 2014; 2(11): 705-710
Published online Nov 16, 2014. doi: 10.12998/wjcc.v2.i11.705

Adjuvant chemotherapy and acute toxicity in hypofractionated radiotherapy for early breast cancer

Vassilis Kouloulias, Anna Zygogianni, Efrosini Kypraiou, John Georgakopoulos, Zoi Thrapsanioti, Ivelina Beli, Eftychia Mosa, Amanta Psyrri, Christos Antypas, Christina Armbilia, Maria Tolia, Kalliopi Platoni, Christos Papadimitriou, Nikolaos Arkadopoulos, Costas Gennatas, George Zografos, George Kyrgias, Maria Dilvoi, George Patatoucas, Nikolaos Kelekis, John Kouvaris

Vassilis Kouloulias, Efrosini Kypraiou, John Georgakopoulos, Zoi Thrapsanioti, Ivelina Beli, Eftychia Mosa, Maria Tolia, Kalliopi Platoni, Maria Dilvoi, George Patatoucas, Nikolaos Kelekis, 2^nd Department of Radiology, Radiotherapy Unit, Attikon University Hospital, 12462 Athens, Greece

Vassilis Kouloulias, Anna Zygogianni, Christos Antypas, Christina Armbilia, Costas Gennatas, John Kouvaris, 1^st Department of Radiology, Radiotherapy Unit, Aretaieion University Hospital, 12462 Athens, Greece

Anna Zygogianni, George Kyrgias, Radiotherapy Department, Larisa University Hospital, 12462 Athens, Greece

Amanta Psyrri, Medical Oncology Unit, Attikon University Hospital, 12462 Athens, Greece

Christos Papadimitriou, Department of Clinical Therapeutics, Alexandra Hospital, 12462 Athens, Greece

Nikolaos Arkadopoulos, 4^th Surgical Clinic, Attikon University Hospital, 12462 Athens, Greece

George Zografos, 1^st Propaedeutic Surgical Clinic, Medical School, Ippokration Hospital, 12462 Athens, Greece

Author contributions: All authors contributed in this paper.

Correspondence to: Zoi Thrapsanioti, MSc, Medical Physicist, 2^nd Department of Radiology, Radiotherapy Unit, Attikon University Hospital, Radiotherapy, Rimini 1, XAIDARI, 12462 Athens, Greece. zoi313@gmail.com

Telephone: +30-694-4186670 Fax: +30-210-5326418

Received: April 29, 2014
Revised: September 23, 2014
Accepted: October 14, 2014
Published online: November 16, 2014

Core Tip

Core tip: The adjuvant radiotherapy for early breast cancer after lumpectomy is an established treatment. Hypofractionation is an attractive approach and the trend nowadays towards new techniques involving hypofractionation is huge, mainly due to the long waiting lists, patients’ desire for fast treatment, better planning of radiotherapy with computed tomography-based target definition and better dose homogeneity assured by 3D conformal planning. The aim of the current study is to evaluate the potential effect of previous chemotherapy to the acute skin toxicity and the local control followed for 2 years in patients with breast cancer, treated with hypofractionated radiotherapy regimen.