Pegaspargase induced multiple organ failure with acute lymphoblastic leukemia: A case report

Table 1 Time course of liver function and kidney function after treatment with pegasparaginase

Date	TB, (μmol/L)	DB (μmol/L)	TP (g/L)	Alb (g/L)	ALT (U/L)	AST (U/L)	ALP (U/L)	γ-GT (U/L)	TBA (μmol/L)	eGFR (mL/min/1.73m2)
2020/10/31	8.4	1.8	71	42	117	73	83	56	/	/
2020/11/27	24.6	8.2	44	27	27	16	73	49	/	129
2020/12/4	31.7	17.4	52	29	121	89	187	235	/	124
2020/12/7	99.1	66.7	44	24	177	148	187	363	/	120
2020/12/10	212.2	133	44	25	235	225	499	669	/	125
2020/12/19	349.4	194.2	55	30	3018	8637	1425	876	/	131
2020/12/21	387.8	265.3	47	23	2115	5666	895	445	179.6	15
2021/1/2	476.5	306.7	41	23	51	144	177	235	79	57
2021/1/14	577.9	387.8	32	17	14	60	135	166	131.8	59
2021/1/16	593	360.7	54	34	23	65	158	181	83.7	72
2021/2/1	342.4	180.6	45	32	121	112	580	276	121.6	110
2021/2/8	317.7	218.3	53	38	162	150	363	210	102.3	110
2021/2/15	306	169	55	37	155	141	237	395	81.3	113
2021/3/1	196.9	109.1	47	32	111	108	276	424	64.9	115
2021/3/22	130.9	74.1	45	28	62	91	317	303	110.6	99
2021/4/1	116.4	66.2	47	29	61	86	354	271	157.5	102
2021/5/7	62.5	33.5	55	34	82	92	243	86	/	80
2021/6/24	45.3	21.8	61	34	50	30	194	73	/	/

γ-GT: γ-glutamyl transpeptidase; Alb: Albumin; ALP: Alkaline phosphatase; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; DB: Direct bilirubin; eGFR: Glomerular filtration rate; TB: Total bilirubin; TBA: Total bile acid; TP: Total protein.