Case Report
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 6, 2025; 13(13): 100735
Published online May 6, 2025. doi: 10.12998/wjcc.v13.i13.100735
Pegaspargase induced multiple organ failure with acute lymphoblastic leukemia: A case report
Su-Xia Bao, Xiao-Ling Yuan, Lei Yan, Jie Xu
Su-Xia Bao, Xiao-Ling Yuan, Lei Yan, Jie Xu, Department of Infectious Diseases, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
Author contributions: Bao SX, Yuan XL and Xu J contributed to research design; Bao SX, Yuan XL, Yan L and Xu J contributed to data acquisition; Bao SX contributed to manuscript writing and funding; Yuan XL, Yan L and Xu J contributed to critical revision; Xu J contributed to administration and technical support.
Supported by National Natural Science Foundation of China, No. 82100625, and Zhejiang Provincial natural Science Foundation of China, No. Q20H030013.
Informed consent statement: The patient agreed to the publication of the case study, and provided written informed consent.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest regarding the publication of this paper.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jie Xu, MAMS, Chief Doctor, Department of Infectious Disease, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, No 280 Mohe Road, Baoshan District, Shanghai 201900, China. dr.xu@aliyun.com
Received: August 24, 2024
Revised: November 10, 2024
Accepted: December 9, 2024
Published online: May 6, 2025
Processing time: 139 Days and 21.8 Hours
Core Tip

Core Tip: We reported a rare patient with acute lymphoblastic leukemia, who suffered from multiple organ failure following the first application of pegaspargase. To date, only one patient has been reported and the patient died due to multiple organ failure in the reviewed word literature. In the article, although the patient had two rare phenomena reflecting poor prognosis, the patient was the first case of successful treatment. Two rare phenomena including inconformity between clinical manifestation and liver function, and persistent low AFP concentrations from subacute liver failure patients will be discussed in this patient.