Clinical significance of platelet mononuclear cell aggregates in patients with sepsis and acute respiratory distress syndrome

Table 1 Comparison of general data between the two groups of patients (mean ± SD), n (%)

	Study group (n = 30)	Control group (n = 42)	χ2/t	P value
Male/female	16/14	25/17	0.475	0.523
Age	51.6 ± 11.4	48.6 ± 14.7	1.234	0.224
Infection			1.587	0.904
Urinary tract infection	4 (13.3)	5 (11.9)
Hematogenous infection	3 (10)	4 (9.5)
Abdominal infection	6 (20)	8 (19.1)
Pulmonary infection	15 (50)	22 (52.4)
Others	2 (6.7)	3 (7.1)
Microbiology			2.88	0.518
Fungus	3 (10)	5 (11.9)
G-	12 (40)	17 (40.5)
G+	5 (16.7)	8 (19)
Mixed infection	6 (20)	7 (16.7)
Unknown cause	4 (13.3)	5 (11.9)
PaO2/FiO2	141.85 ± 29.44	145.35 ± 30.28	11.27	0.912

Table 2 Comparison of platelet neutrophil aggregates, platelet aggregates, and platelet-mononuclear cell aggregates between the two groups (mean ± SD)

Groups	n	PNAs (%)	PLyAs (%)	PMAs (%)
Study group	30	14.15 ± 8.93	15.42 ± 6.97	27.18 ± 6.141
Control group	42	13.87 ± 9.24	14.78 ± 3.24	17.29 ± 2.05

¹Compared to the Control groups, the serum levels of platelet-mononuclear cell aggregates increased in sepsis patients with acute respiratory distress syndrome (P < 0.05).

APACHE II: Acute Physiology and Chronic Health Evaluation II Scores; PMAs: Platelet-mononuclear cell aggregates; PNAs: platelet neutrophil aggregates; PLyAs: Platelet aggregates.

Table 3 Comparison of Acute Physiology and Chronic Health Evaluation II Scores between the two groups (mean ± SD)

Groups	n	APACHE II
Study group	30	35.17 ± 5.441
Control group	42	23.39 ± 4.24

¹Compared to the Control groups, the Acute Physiology and Chronic Health Evaluation II scores increased in sepsis patients with acute respiratory distress syndrome (P < 0.05).

APACHE II: Acute Physiology and Chronic Health Evaluation II Scores.

Table 4 Area under the curve for various parameters

Parameter	AUC	SE	P value	95%CI
				Upper limit	Lower limit
PMAs	0.957	0.022	< 0.05	0.914	0.974
APACHE Ⅱ	0.93	0.021	< 0.05	0.872	0.981

APACHE II: Acute Physiology and Chronic Health Evaluation II Scores; PMAs: Platelet-mononuclear cell aggregates; AUC: Area under the curve.

Table 5 Diagnostic values for various parameters

Parameter	Cutoff value	Sensitivity	Specificity	Positive predictive value	Negative predictive value
PMAs	8.418	0.819	0.947	0.956	0.819
APACHE Ⅱ	17.115	0.837	0.844	0.829	0.877

APACHE II: Acute Physiology and Chronic Health Evaluation II Scores; PMAs: Platelet-mononuclear cell aggregates.