Targeting nuclear factor erythroid 2-related factor 2-regulated ferroptosis to treat nervous system diseases

Table 1 Main content of the original paper

Item	Details
Background	NRF2, a pivotal transcription factor in the antioxidant network, has been reported to play a crucial role in nervous system diseases. susceptible to oxidative damage. Consequently, the regulatory capacity of NRF2 and its potential clinical applications in these diseases have generated increasing interest in the scientific community
Methods	Data were gathered through a systematic review of the literature on NRF2 and nervous system diseases from the Web of Science Core Collection database and used the bibliometric tool CiteSpace for analysis
Results	Recent years have seen a rise in NRF2-related literature on nervous system diseases, with China holding a dominant position in terms of article publications, financial investments, and the number of authors with the highest publication records. NRF2 research hotspots have evolved from focusing solely on antioxidants to include anti-apoptosis and active ferroptosis
Conclusion	China should prioritize enhancing the quality and impact of research articles. Research on NRF2 in nervous system diseases has expanded to encompass various cell death mechanisms. Further clinical investigations of NRF2-related medications are necessary

NRF2: Nuclear factor erythroid 2-related factor 2.