Analysis of long-term outcome of modified gastric bypass for type 2 diabetes mellitus in Chinese patients

Table 1 Changes in weight and body mass index before and after laparoscopic gastric bypass surgery (mean ± SD)

	Preoperative (n)	5 years after surgery (n)	P value
Weight (kg)	84.6 ± 17.3 (37)	67.1 ± 12.2 (37)a	0.001
BMI (kg/m2)	30.9 ± 5.0 (37)	24.6 ± 3.9 (37)a	0.001

^aP < 0.05, the differences were statistically significant when compared with the preoperative period.

BMI: Body mass index.

Table 2 Changes in fasting plasma glucose and glycated hemoglobin before and after laparoscopic gastric bypass surgery (mean ± SD)

	Preoperative (n)	5 years after surgery (n)	P value
FPG (mmol/L)	7.4 ± 3.4 (37)	6.5 ± 1.3 (37)	0.619
HbA1c (%)	8.2 ± 1.7 (36)	6.5 ± 0.9 (36)a	0.001

^aP < 0.05, the differences were statistically significant when compared with the preoperative period.

FPG: Fasting plasma glucose; HbA1c: glycated hemoglobin.

Table 3 Comparison of combinations before and after laparoscopic gastric bypass surgery

Abnormalities	Preoperative (%)	5 years after surgery (%)	P value
Antihyperglycemic drug	37 (100)	11 (29.7)	0.001a
Antihypertensive drug	7 (18.9)	2 (5.4)	0.075
Dyslipidemia	18 (50.0)	9 (2.05)	0.028a
Transferase	9 (25.0)	0 (0)	0.002a
CREA	1 (2.8)	1 (2.9)	0.984
UA	2 (5.6)	5 (13.9)	0.429
HGB	1 (2.7)	6 (18.2)	0.038a
ALB	1 (2.7)	1 (2.9)	1.000
SF	1 (3.0)	8 (25.0)	0.013a
FA	0 (0)	0 (0)	-
VB12	1 (3.0)	3 (11.1)	0.318

^aP < 0.05, the differences are statistically significant when compared with the preoperative period.

CREA: Creatinine; UA: Uric acid; HGB: Haemoglobin; ALB: Albumin; SF: Serum ferritin; FA Folic acid; VB₁₂: Vitamin B₁₂.

Table 4 Changes in blood lipids before and after laparoscopic gastric bypass surgery (mean ± SD)

	Preoperative (n)	5 years after surgery (n)	P value
TG (mmol/L)	2.1 ± 1.9 (36)	1.2 ± 0.7 (36)a	0.037
CHO (mmol/L)	4.5 ± 0.9 (36)	4.3 ± 0.7 (36)	0.504
HDL (mmol/L)	1.1 ± 0.3 (35)	1.4 ± 0.3 (36)a	0.001
LDL (mmol/L)	2.8 ± 0.6 (36)	2.6 ± 0.6 (36)	0.336

^aP < 0.05, the differences were statistically significant when compared with the preoperative period.

TG: Triglycerides; CHO: Total cholesterol; HDL: High-density lipoprotein; LDL: Low-density lipoprotein.

Table 5 Changes in other measures before and after laparoscopic gastric bypass surgery (mean ± SD)

	Preoperative (n)	5 years after surgery (n)	P value
ALT (U/L)	33.5 ± 18.7 (36)	20.7 ± 6.8 (36)a	0.004
AST (U/L)	21.6 ± 9.0 (36)	22.1 ± 7.2 (35)	0.694
CREA (μmol/L)	54.3 ± 16.2 (36)	58.4 ± 15.8 (35)	0.601
UA (μmol/L)	320.1 ± 115.0 (36)	313.4 ± 95.0 (36)	0.336
HGB (g/L)	133.9 ± 14.3 (37)	126.3 ± 19.2 (33)	0.366
ALB (g/L)	44.9 ± 2.8 (37)	44.5 ± 2.7 (34)	0.665
SF (ng/mL)	137.6 ± 138.5 (33)	32.1 ± 29.4 (32)a	0.001
FA (ng/mL)	18.1 ± 6.7 (32)	17.1 ± 8.6 (28)	0.308
VB12 (pg/mL)	563.3 ± 496.4 (33)	420.7 ± 304.6 (27)	0.196

^aP < 0.05, the differences were statistically significant when compared with the preoperative period.

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; CREA: Creatinine; UA: Uric acid; HGB: Haemoglobin; ALB: Albumin; SF: Serum ferritin; FA: Folic acid; VB₁₂: Vitamin B₁₂.